Effect Of Yixin Capsule On Apoptosis In Rabbit Models Of Acute Myocardial Ischemia

On the basis of "activating blood circulation to dissipate blood stasis" and "activating Qi and eliminating phlegm" and their many-year clinical experience, many experts hold the view that the pathogenic mechanism of coronary heart disease is due to stagnation of blood stasis in the intestinal collateral and stagnation of QI causing phlegm retention. They employ the method of to research and produceYixin Capsule. Through years of preliminary clinical observation, it has ideal healing power. The national Bureau of Drugs Supervision has sanctioned its entering the third clinical stage now.Duplicate the animal models-rabbits with myocardial ischemia by way of coronary ligation. Tongxinluo is taken as the positive control drug. The mechanism of Yixin Capsule is detected by observing its effect on the pathomorphology, ultrastructure and cell apoptosis of rabbits' ischemic myocandial cells. This provides theoretical proof for the prevention of coronary heart disease with traditional Chinese medicine.The experimental results reveal that Yixin Capsule can improve the pathologic picture and uhrastructure of myocandial cells and resist the over apoptosis of the myocardial cells. The results, compared with the control group treated with Luoxintong are obiously wuperiorto the model group. So we can say Yixin Capsule is an effective medicine in the prevention and treatment of coronary heart disease. This lays solid foundation for the farther research and use ofYixin Capsule.