A Clinical Study Of Properities Of False-negative Responses In Automated Perimetry

Objective:To study the properties of false-negative responses of visual field tests on Octopus 101 perimetry through a series of clinical delectations and investigations.The study was divided into three independent portions:1, To detect intereye differences of false negative responses rate(FN) and mean deviation(MD) in glaucoma patients with unilateral visual field defect. 2,To study the discrepancy of FN between normal subjects,glaucoma patients and non-glaucoma patients with visual field damage,and relationships between FN and visual field indexes.3,To investigate stabilization of FN in glaucoma patients and chang of the correlation between FN and visual field defect. Methods:1, Glaucoma patients with nomal visual field in one eye and damaged in another who performed automated perimetry between Jan 2000 and Oct 2002 were involved in this study. Intereye differences of false negative FN and MD were analyzed; 2,A prospective study was performed on NS(30cases),GP(68 cases),NGP(21 cases).One eye was selected at radom for test.OctopuslOl perimetry was performed on each subject with programme G2(Oct2001-Oct2002).Diffrerences of FN between groups and correlation factors were analyzed .3,A prospective follow-up study was carried out on NS(25 cases) and GP(25 cases).All subjects handled 3-4 successive automated perimetry in a 8-months duration (Oct2001-Oct2002) and indexes observed similar to part 2.Results:1, FN between nomal eyes and damaged eyes was significant different(P<0.001),and this kind of differences has no relationship with consequence of the tests.No significant differences were found in visual acuity,IOP,pupil diameter intereyes(P>0.05). 2,No significant differences of visual acuity,IOP,and pupil diameter was found between NS,GP,and NGP(P>0.05).There was no correlation between FN and these factors for all groups.FN,SF of NS group were far lower than those of GP and NGP(P<0.01).Ingeneral,the distributing of false negative responses was equalence in every time section.3,Relative tranquilization was kept for FN in a 8-months period follow-up tests,butcounterpoise was also observed in several patients and MD changed meantime.Conclusions:1,FN reflects visual field state of glaucoma patients in some extent while it is in-properiate to take it as a predict index of attentiveness of the patients.2,Closely relationship were found between FN and MD,SF,ADL and LF in someextent.To explain it from test principle ,it was linked to the increasing of the thresholdvariation in the border of the absolute visual field defect.3, FN could be a indication of visual field defect .especially local visual field with deepdepression.