The Values And Clinical Significance Of Soluble Fas And Soluble FasL In Forecasting The Possibility That The Patients With Diabetes Mellitus Suffer Tuberculosis

Objective To explore the values and clinical significance of soluble Fas and soluble FasL in forecasting the possibility that the patients with diabetes mellitus suffer tuberculosis.Methods The content of the soluble Fas (sFas) and the soluble Fas ligand (sFasL) in the plasmas of patients with the tuberculosis, diabetes mellitus or diabetic patients with tuberculosis were examined respectively with enzyme-linked immuno- sorbent assay (ELISA) .Results The levels of the sFas and sFasL in the diabetic patients with tuberculosis, tuberculosis and diabetes were significatively higher than in controls. (5. 54±1. 94/2. 18± 0. 91, P<0. 05). The level of sFasL in the plasmas of the diabetic patients with tuberculosis was significatively lower than that of the patients with diabetes (518. 72±252. 23/ 1904. 37±318. 55, P<0. 01) or the patients with tuberculosis (518. 72±252. 23 /713. 51 ±285. 36,P<0. 05); If 1500pg/ml was regarded as limit, the sensitivity, the specificity and the rate of diagnosing the diabetic patients with tuberculosis were 95% (19/20), 80.95%(17/21) and 87. 80%(36/41) respectively.Conclusions In diabetic patients with tuberculosis, patients with tuberculosis or patients with diabetes, there was a metabolic disregulation of the sFas and the sFasL in the plasmas which fluented the apoptosis of the immune cells and attributed the occur of tuberculosis in diabetes. On the other hand, the variety of sFas and the sFasL in plasma in patients with the tuberculosis, diabetes mellitus or diabetic patients with tuberculosis could be used to value the states and prognosis.