| ObjectiveThe purpose of this study was to summarize the hemodynamic characteristics and findings of dynamic-enhanced magnetic resonance (MR) imaging with gadolinium-DTPA (Gd-DTPA) of hepatocellular carcinoma (HCC) and to probe into the diagnostic value for HCC of contrast-enhanced MR imaging with mangafodipir trisodium, and the clinical application value of the two methods was compared primarily. Materials and methodsTo analyzing before and after dynamic contrast-enhanced MR imaging of fifty-nine patients with HCC. and to observe changes of signal intensity of lesion in plain scanning, arterial phase, portal venous phase and delayed phase and to show the capsule of tumor, cancer embolus in portal vein and metastases in liver on TI-weighted images.According to the evolvement of signal intensity of lesion, dynamic enhancing pattern was divided into four types: (1) arterial enhancement type: the signal of the lesion was low on plain scanning, and was near or higher than the liver in arterial phase, and was lower than the liver in portal venous and delayed phase. The pattern of contrast enhancement was hypo-hyper-hypo-hypointense. (2) Double blood supplied enhancement type: the signal of lesion was higher or near than the liver in arterial phase and portal venous phase, and was lower than the liver in delayed phase. The enhanced pattern was hypo-hyper-hyper-hypointense. (3) Portal venous enhancement type: the signal of lesion was lower than the liver in arterial phase, and was higher or near the liver in portal venous phase, and was lower than the liver in delayed phase. The pattern of enhancement was hypo-hypo-hyper-hypointense. (4) Poor blood supplied enhancement type: the signal of lesion was lower than the liver in arterial, portal venous and delayed phase. Signal intensity of the lesion and adjacent hepatic parenchyma and standard deviation of background noise before and after contrast-enhanced MR imaging was measured in fifteen patients with HCC who had original images on workstation. Signal-to-noise ratio (SNR) of the lesion and the hepatic parenchyma and contrast-to-noise ratio (CNR) between the lesion and adjacent hepatic parenchyma were calculated.Nineteen patients in adult who had been suspicious of hepatic mass in clinic or recurrence and metastasis after treatment of HCC underwent imaging with contrast-enhanced MR imaging with Mn-DPDP. The sequences included fast low angle shot (FLASH), fat-suppressed (FS) FLASH, in-phase (IP) and opposed-phase (OP) FLASH of Tl-weighted imaging. Characteristic of image of fifteen patients with HCC was analyzed. Signal intensity of the lesion and adjacent hepatic parenchyma and standard deviation of background noise before and after contrast-enhanced MR imaging was measured in these patients. SNR, CNR and signal enhancement ratio (SER) were calculated.Analysis of variance, X2 test and t test were used in the study. ResultsDynamic enhanced MR imaging with Gd-DTPA: (1) Of fifty-nine patients with HCC, the artery type was 88.4% (52/59), and double blood supply type was 8.47% (5/59), and poor blood supply type was 8.47% (5/59), portal vein type was not showed. The sizes of the lesion had no significant difference in various enhanced pattern of HCC. (2) Of fifty-nine patients with HCC, pseudocapsule in plain scanning, dynamic enhanced arterial phase, portal venous phase and delayed phase was showed in sixteen, thirteen, twenty and twenty-seven patients respectively. Total presence rate of pseudocapsule was 45.76% (27/59) , and was highest in delayed phase (P=0.015). (3) SNR> CNR of the lesion and adjacent hepatic parenchyma before and after contrast-enhanced MR imaging in the artery type had significant difference (.P<0.001) , and CNR was largest in arterial phase.Contrast-enhanced MR imaging with Mn-DPDP: (1) Of fifteen patients with HCC, signal intensity of lesion was higher than the liver in four patients and still was high in after twenty-four hours in all; signal of the lesion was lower than the liver in nine patients and was higher than the liver...
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