A Long Term Following-up Study Of The Influence Of Congenital TORCH Infections On Children's Physical, Eyes And Intelligence Development

Objective The goal of this study is to learn about the long term influence of congenital TORCH infections on children by observing their physical, eyes and intelligence development.Method According to our previous information, we examined 75 children aged at least 46 months. They were divided into three groups according to cord blood TORCH serial antibody. Group A: IgM is positive; Group B: IgG is positive; Group C: antibody is negative. Three physical development indexes were analyzed respectively when they were 0 day, 42 day, 3 month, 6 month, 9 month and 12 month; the results of the eyes examination and 1Q were evaluated. Results1. 4 patients of group A were found clinical abnormity. One died of severe pneumonia at 40 day (1UGR); A case(born with derma maculopapule) of group A has no binocular stereopsis and his optic disc is smaller than normal child of the same age. One suffered from hip joint dislocation; one was diagnosed cerebral paralysis at 12 month. There was no similar case of group B and C.2. Statistical analysis of the three developmental indexes of 0 day, 42 days, 3 months, 6 months, 9 months, 12 months of three groups have no significant difference (F>0.05).3. No significant difference was shown when FIQ and P1Q were analyzed, but statistical significant difference in verbal IQ among three groups (/5<0.05), group A has lower V1Q than the other two groups.4. The abnormality rate of standard logarithmic vision and binocular stereo-acuity in group A are higher than group B and C, but has no significant difference (/*>0.05).5. Compared with normal children on VHP, Group A have a lower spatial frequency sensibility; the latency of peak N75 and peak P100 is evident earlier and have no difference through stimulation of the different spatial frequency check; the amplitude discrepancy of the 13 lead and 15 lead is more evident.6. Compared with normal children on ERG, the amplitude of b wave is rather weaker. Conclusions1 In this study, it demonstrates that congenital TORCH infections may have no adverse influence on the children's physical development but on the children's viscera, IQ and eyes development.2. Whether born with symptomatic or asymptomatic congenital TORCH infections, progressively damages may occur. These patients should be treated to reduce or control these damages.3. The outcomes of congenital TORCH infections are severe. The pregnant women who had acute or recurrent TORCH infections should be treated. We should give them the advice to end a pregnancy if it's necessary.4. We should lake steps to raise the diagnostic rate of congenital TORCH infections by the combination of different ways in order to treat these patients timely.