Study On The Dynamic Changes And The Clinical Significance Of Serum Concentrations Of Protein S100B In Cerebral Infarction

Objective: To study the serum concentrations of protein S100B in early patients with cerebral infarction after onset, and to evaluate their association with neural functional deficit degree in admission, activities of daily living (scale), the size of cerebral infarction, types classified according to OCSP and average arterial pressure, body temperature, consciousness, leukocyte count, etc.Methods: The concentrations of serum S100B were determined by ELISA in 34 patients with cerebral infarction at days 1,3 after onset, in 31 patients at day 7, and in 34 age-sex-matched control subjects. The neurological status was evaluated by the standard of clinical neural functional deficit degree score in patients with CI in admission. Functional outcome was measured with the activities of daily living (ADL) Barthel index score at discharge from the hospital. The size of infarcted brain area was based on cranial CT data. All patients were classified according to OCSP. On taking vein blood, we measured blood pressure, body temperature, consciousness, ocular movement, leukocyte count and blood sugar.Results: Elevated concentrations of S100B (>0.2ug/L) were observed respectively in 13, 18, and 8 patients with CI of 34 at days 1, 3 after onset, in 31 at day 7, but in none of the control subjects. Serum concentrations of protein S100B have positive association with the neural functional deficit degree in admission, and negative association with the activities of daily living score at discharge from the hospital.The larger CI, The higher the serum concentrations of S100B. Increased concentrations of serum S100B at day 3 after stroke onset were correlated with body temperature, consciousness, ocular movement, leukocyte count, and the size of CI, but not with average arterial pressure, and blood surge.Conclusions: Increased serum concentrations of S100B in patients with CI indicate severe cerebral cell injury. Serum concentrations of S100B reflect CI degree and extent. Therefore, serum S100B may serve as a auxiliary prognostic index and have a predictive value for outcome after acute infarction. Farther, it may be helpful for therapeutic decisions in acute cerebral infarction.