A Clinic Comparison Of Myocardial Protection Between Warm Beating Heart And Cold Crystalloid Cardioplegia

Objective Recent interest in the use of warm beating heart is based on theoretical advantages over the traditional method of hypothemic myocardial protection. This study was designed to compare the effects of warm beating heart with cold crystalloid cardioplegia on the ischemic damage, reperfusion injury, arithmia and ultrastruture changes, and to investigate the theoretical basis of myocardial protection of warm beating heart.Methods Twenty patients undergone mitral valve replacement were selected and randomly divided into two groups- group of warn beating heart (BH,w=10) and group of cold crystalloid cardioplegia (CCP,n=10). Venous blood examples were taken to assess myocardialtroponinl(cTnl) , creatinekinase-MB(CK-MB) and superoxidedismutase ( SOD) before pre-cardiopulmonary bypass, 1 hour after aortic unclamp (1 hour after superior and inferior vena cava unclamp in group BH) and 6 -.24 ,.48, 7 2 hours post-operatively. Electrical cardiographs were recorded 3 hours before and after operation. Right atrial specimens were taken 10 minutes before aortic clamp and 30 minutes after aortic unclamp for elec-tropic microscopic examination.Result cTnl, CK-MB and SOD levels in two groups 1 hour after aortic unclamp, 6, 24, and 48 hours after operation were significantly different. (P