| Bovine pericardium(BP) is a kind of natural biomaterial which is mainly composed of type I collagen. Up to the present, BP is usually utilized as valve , artificial vein, repairing-material and so on for its appropriate mechanical property. However, in this paper, EP is firstly studied for degradable biomaterial. Modifying methods used to control the degradation of BP were discussed; The degradation behavior of several modified BP were investigated and compared; Based on these studies, cell-compatibility , immunogenicity and permeability of DFBP were investigated.BP was cross-linked by EP and GA respectively, which resulted in prolonged degradation; Accelerated degradation was obtained through Ca(OH)2 and trypsin processing. Ca(OH)2 could separate and swell collagen fibre; Trypsin not only could loosen fibre , but also digested the components of antigen on BP. Studies of the degradative performance of several modified BP in vitro indicated the sequence of their degradation rate: EPBP |
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