The Effects Of Vitamin K On Bone Metabolism Of Infant And Gravida During Perinatal Stage

Objective To study the effects of vitaminK on bone metabolism of infant and gravida during the per inatal period. Methods 50 pregnant women were divided into throe randomized groups: the vitamin K treament group (N =15 was given a vitamin K oral dose of 5 mg from the thirty-seventh week of pregnancy to delivery , association group (N = 14) was given vitamin K according to above and vitamin D supplement of 200 ID/day during the last four worths of pregnancy, control group ( N=21 ) had not been intervened. Venous serum samples were obtained at deliveryfrom the women and the cord blood, Urine samples were alsocollected from the first voiding. We measured osteocalcin (OCtotal), non- or undercarboxylated osteocalcin ( ucOC ) bone-specific alkaline phosphatase(BALP), 25-hydroxyvitaminD3, calciurrrcreatinine ratios(Ca/Cr), and Hydroxyproline-creatinine ratios (HP/Cr) and calculated The percent of un-carboxylated osteocalcin (%ucOC, ucOC/OCtotal) to estimate the effects of vitamin K on bone metabolism of infantand gravida. Results The percent of uncarboxylated osteocalcin of neonate and pregnancy were both lower in the vitaminK supplement, group than in the control group ( 38. 2%> 4. 6%, P <0. 001; 15%, 6.9%, P 208. 16mg/g, /' <0. 05), and the level of urine HP/Cr decreased a little. Cord bloodpercent uncarboxylated of osteocalcin concentrations correlated with those of maternal serum(r =0. 634, P <(). 001 ). Cord blood OC, ucOC, percent uncarboxylated of osteocalcin, BALP and urine HP/Cr concentrations were significant higher than those of maternal serum. Conclusion Oral administration of vitamin K, during late pregnancy could improve the level of vitaminK in neonatesand gravidas, therefore provides an effective prophylaxis for the occurrence of hemorrhage caused .by deficiency of vitamin K. Vitamin K supplytnent may be have a benefit roleon the bone formation or developing in neonate and preventing pregnant bone mass loss, so rnaintenant equilibration of bone metabolism duringperinatal stage. Vitamin D supplyment hasn' t any effect-tion on the carhoxylation of ostcocalcin.