1.Impact Of Early Growth Retardation On Pancreatic β-cell Function Of Rats At Adult Stage 2.Contrast The Efficiency Of Improving Type 2 Diabetes Pancreatic β Cell Function Between Nateglinide And Repaglinide

Objective: To explore the impact of early growth retardation on pancreatic β-cell function of rats at adult stage. Methods: Pregnant female rats were offered 50% of control intake during the last week of pregnancy and suckling period, so as to induce offspring early growth retarded. An intraperitoneal injection glucose tolerance test and hyperglycemic clamps were applied to the adult offspring Results: Contrasted with that of the controls, Area Under Curve of Glucose(AUCg)and Area Under Curve of Insulin(AUCi)after intraperitoneal injection of glucose were markedly elevated in the adult offspring with early growth retardation (P<0.05), while the ratio of AUCg/AUCi decreased significantly (P=0.01). During hyperglycemic clamps, the steady-state insulin concentration of the offspring with early growth retardation decreased significantly versus controls (P=0.02). Conclusion: Early growth retardation results in pancreatic β-cell disfunction of rats at adult stage.