| Cardiovascular diseases have become one of the two kinds of most serious diseases that threaten human beings (the other is cancer). It is a critical prerequisite to understand the normal progress of cardiovascular development and the mechanisms underlying the causes of this kind of diseases, so that it is possible to cure the disease. As it known, mistakes in spatiotemporal expression of critical genes result in congenital cardiovascular diseases. Furthermore, studies on high risk population of cardiovascular disease have also suggested the relationship between noncongenital cardiovascular diseases and genetic factors. In order to promote our understanding for cardiovascular development and discovery the molecular regulatory mechanisms during this progress, our laboratory performed a large scale scanning project to search and clone cardiac developmental candidate gene.WD40 repeat protein 26 (WDR26) is one of the candidate genes that the author of this article obtained from the scanning with bioinformatics methods. The cDNA of WDR26 is 1542 bp, coding for a protein, WDR26, of 514 aa, which contains a consensus domain of 5 WD40 repeats. In many species, such as mouse, rat, fly, and et.al, we discovered the homologues of WDR26 and they present highly consensus during evolution, which suggests the potential importance of this subfamily.Expression assays present that WDR26 is expressed with different pattern at fetal and adult stages and strongly expressed in skeletal muscles. The results of transcription activity assays show that overexpression of WDR26 in COS7 cells can remarkably inhibit the transcription-stimulation activity of ELK-1 and SRE, which are downstream effectors of MAPK pathway. Furthermore, overexpression of WDR26 can slightly promote the growth of Hela cells. In conclusion, we suggest that WDR26 probably takes part in regulation of cell life progress through acting a role in MAPK pathway.
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