Study On Peripheral Lymphocyte Apoptosis In Patients With Alopecia Areata

Objective To study the expression of CD95 and bcl-2 in the peripheral lymphocytes and the role of them in the pathogenesis of Alopecia Areata(AA). Methods CD95 and bcl-2 positive lymphocytes were sorted out by flow cytometry. Results The expression of CD95 in AA patient was significantly increased compared with those of normal controls, whereas the difference of bcl-2 expression between the two groups was not significant. Conclusions Over-expression of CD95 in the peripheral lymphocytes triggers cell apoptosis in the hair follicles, and promotes the development of alopecia areata.