| Objective To investigate the effect of long-termadministration of morphine on sex hormone, bone mineral density and biochemical markers of bone metabolism infemale rats and correlation analysis. Methods 30 femaleSD rats (3 months old )were randomly divided into 2 groups. The rats in long-term exposure to morphine group were subcutaneously injected by gradually increasing dose of morphine (from 3mg/kg to 44mg/kg, 12weeks),the rats in control group were injected with saline. Rats in bothgroups were sacrificed at the end of 12th week. ResultsThe rats in morphine group showed lower E2,PROG and LH levels, serum tartrate-resistant acid phosphatase (TRAP) and calcium, urinary hydroxyproline (HOP) and calciumwere significantly higher in morphing group than on control group., BMD in lumbar vertebrate and distal femur in morphine group rats significantly decreased, comparedwith control rats. Conclusion After long-termadministration of morphing, bone absorption was markedly higher than bone formation in female rats, biochemical markers of bone absorption metabolism was significantly negatively correlated with E2, indicating that hormone replacement therapy could be used to decrease bone loss.
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