Analysis Of Clinical Characteristics And Drug Sensitivity Tests Of Lower Respiratory Tract Infection Caused By Bacterial

Objective To investigate the bacterial resistance of clinical isolates from the lower respiratory tract infection in First affiliated hospital to SuZhou University.Methods Antimicrobial susceptibility of clinical isolates were tested by Kirby-Bauer methods.Results The number of the yearly resistant clinical isolates was up.Of the yearly clinical isolates , the yearly Gram positive organisms were increasing. The resistant rates to ciprofloxacin, gentamicin, clindamycin were no difference in E. faecalis and E.faecium. E. faecalis and E.faecium to vancomycin were sensitive. The sensitive rates to penicillin and ampicillin were higher in E. faecalis than in E.faecium. The sensitive rates of E.faecium. to tetracycline were higher than that of E. faecalis.34 strains of Enterococcus were intermediated to vancomycin. 12 strains of Enterococcus to vancomycin were resistant organisms.MRSA(methicillin resistant Staphylococcus aureus) ,MRCNS(methicillin resistant coagulase negative Staphylococcus) was 34.6% and 47.25% of staphylococci respectively. The resistance rates to ciprofloxacin, trimethoprim-sulfamethoxazole, clindamycin were significantly higher in MRS than MSS. The resistance rates of MRSA and MRCNS to normal antimicrobial have no difference. No vancomycin intermediated Staphylococcus strains were found . The ESBLs (extended-spectrum beta-lacatamas) producing strains in Klebsiella pneumoniae andEscherichia coli were 22.18% ,40.30% respectively. The resistant rates of ESBLs producing strains to common antimicrobial agents were much higher than those of ESBLs nonproducing strains. All Klebsiella pneumoniae and Escherichia coli were sensitive to imipenem.The sensitive rates of Enterobacter specieces to ciprofloxacin and aminoglycosides were more than 65%, to third generation cephalosporins were 44.50%-68.06%. The sensitive rates to amikacin, ciprofloxacin , ceftazidime and imipenem were more than 70% in Pseudomonas maltophilia and Ancinetobacter spp. The resistance rates of Stenotrophomonas maltophilia to ciprofloxacin were 65.06%,to third generation cephalosporins , imipenem , penicillin and aminoglycosides were resistant.Conclusion Bacterial resistance is still or even a serious clinical problem than before. An unanimous effective strategy for the control of this problem is urgently needed.