| 1. BackgroundDilated cardiomyopathy(DCM) is a heart muscle disease characterised by left ventricular or biventricular dilation and impaired contraction. It was usually found in the youths and middle ages. The majority of patients with DCM have suffered arrhythmia, especially ventricular arrhythmia(VA). Several studies found the malignant or serious ventricular arrhythmia may be one of the causes for sudden cardie death. The relationship between serious ventricular arrhythmia and the left ventricular cavity size was not coincidence from different reports. The purpose of this study was to further evaluate the relationship between malignant ventricular arrhythmia and left ventricle cavity size by studying the data of 75 patients with DCM.2. Material and methods2.1 patientsAll cases were inpatients during June of 2000 to March of 2004. In 75 cases (45 males and 30 females), the mean age was 53 14 years old. The diagnostic standard was accord to the WHO/ ISFC in 1995, and match below items: left ventricular end diamiter diastolic(LVEDd) 50mm, 2-dimensional echocardiography (2-DE) show the whole contraction function of left ventricle impaired. Following diseases were excluded: including arrhymogenic right ventricular cardiomyopathy; ischemic cardiomyopathy; hypertensive cardiopathy; hypertrophic cardiomyopathy; valvular heart disease; chronic pulmonary heart disease ; hyperthyroidism or hypothyroidism heart disease ; peripartum cardiomyopathy; diabetic cardiomyopathy; others' diseases which could influence heart.2.2 MethodsAll patients were checked by Doppler echocardiography, EKG and dynamic electrocardiogram(DCG). Doppler echocardiography were HP5500 type or Vivid7 type produced from United States, and the M type and 2-DE were used for checking at the same time. Left atrial diamiter(LAD) and left ventricular end diamiter diastolic(LVEDd) were measured from left ventricle major axis path, AF patients were measured by 3-5 movie cycle. Arrhythmia were monitored by automatic analysis of dynamic electrocardiogram system of 24 hours, DMS700 type produced from United States and artificial to judge, ventricular arrhythmia were ratinged by Lown's method, 3 ratings definited as malignant ventricular arrhythmia. According to LVEDd, all patients were divided into threegroups(50-59mm group, 60-69mm group, ^ 70mm group), Three groups data were compared . and proceeded statistics analysis, according to the left atrium diamiter(LAD), All patients were divided into two groups(<35mm group and 35mm group), two groups data were compared. And according to the United States New York heart academic association(NYHA) ratings standard, all patients were divided into two groups by cardie function ratings(l,2 ratings group;3,4ratings group).2.3 StatisticsAll statistical procedures were performed with SPSS11.0 software package. Continuous variables were compared by median of the Independent-Sampales T test. Differences in distribution were compared by the Chi-square test or Fisher's exact test if appropriate. P values below 0.05 were considered statistically significant.3. Results3.1 The relationship between left ventricular cavity size and malignant ventricular arrhythmia.Of the three groups, incidence of malignant ventricular arrhythmia were 8 (10.67%), 26 (34.67%), 23 (30.67%), respectively . The incidence of first group was lower than the latter two groups, and remarkable difference was found( P<0.05), no remarkable difference was found between the latter two groups.( P>0.05)3.2 The relationship between cardie function and malignant ventricular arrhythmiaOf the two groups, incidence of malignant ventricular arrhythmiawere 6(9.68%) and 41(66.13%), respectively. The incidence of latter groupwas higher than the fore group, and remarkable difference wasfound(P<0.01).3.3 The relationship between left atrium size and AFOf the two groups, AF incidence was 12(21.4%) and 0, respectively. The incidence of first group was obviously high, remarkable difference...
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