| Objective To evaluate the effect and toxicity of lipiodol-arsenic trioxide emulsion on the treatment of primary hepatic carcinoma by interventional ways, and to explore the feasibility of its application combined with Anthracycline.Methods arsenic trioxide 20 mg and lipiodol were fully mixtured into lipiodol-arsenic trioxide emulsion, which were injected into hepatic artery by catheters in 30 patients with primary hepatic carcinoma. If the patients' conditions progressed when therapy or follow-up (tumor got larger or AFP increased), Anthracycline would be used simultaneously. The effect and toxicity were observed.Results after 1 ~ 3 times of therapy simply with lipiodol-arsenic trioxide emulsion in all of 30 patients, objective response rate was 20% with 6cases of PR, 19 cases of NC and 5 cases of PD. AFP decreased from 11109. 36 + 2920. 82iu/ml to 10001.61 + 2880. 67iu/ml averagely (P>0. 05) . Anthracycline was applied in 11 patients, and tumors got smaller in 8 cases after that. AFP decreased from 13901. 11 ?862. 26iu/ml to 5470. 63 + 2597. 79iu/ml averagely (p < 0. 05 ) . The major toxic side effect were pyrexia, nausea and vomiting, pain in hepatic region, mild bone marrow depression and hepatic damage. No irreversible toxic response occurred.Conclusions Lipiodol-arsenic trioxide emulsion injection via hepatic artery by catheters is effective and less toxic to treat primary hepatic carcinoma. We are long for enhancing the effect by application combined with Anthracycline.
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