Monte Carlo Simulation And Analysis Of Radiation Damage To Cells In Boron Neutron Capture Therapy

The best therapy technique for tumor can kill tumor cells and has only minor effect on healthy cells. It doesn't meet the two requirements above at the same time for conventional radiation treatment such as 60Co therapy , X ray therapy and stereotactic radiosurgery & radiotherapy at present. Boron neutron capture therapy (BNCT) has a promising development in tumor treatment for it can achieve selectivity at the cellular level.It's very important for BNCT to know the microdosimetry and damage distributing at cellular and subcellular level. The physics process of interaction between energetic ions and tumor cells provides the foundation for researching the microdosimetry and relative biological effect. For lack of laboratory apparatus and technique, it's very hard to observe the micro-process between energetic ions and tumor cells at present. So the interaction between -particle produced from the 10B(n, )7Li neutron capture reaction and tumor cells has been simulated by SRIM code based on Monte Carlo technique in this paper. The biological effect of tumor cells has been studied by analyzing the track and depth of the particles, the deposition of energy and the damage of target. And the deposited energy of the a -particles in the different position of the cell model has also been calculated by the SRIM code in this paper and the structure damage to the tumor cell has been simulated. The computed results are compared and analyzed. The results are very helpful to understand the distribution of microdosimetry at cellular and subcellular level. And this would provide theory and support for BNCT.