An Animal Experimental Study Of Percutaneous Transhepatic Gastrobiliary Duodenal Internal Drainage Therapy For Obstructive Jaundice

Objective To evaluate the safety and efficacy of percutaneous transhepatic gastrobiliary duodenal internal drainage therapy for obstructive biliary, especially refractory obstructive biliary, with an animal experimental study and several technicals points involved in this method discussed. Materials and Methods 20 cases of local ,healthy, crossbred pigs , including 9 males and 11 females ,their common bile ducts were ligated. They were randomly divided into two groups :One group (Group A ,n=10 ) called percutaneous transhepatic gastrobiliary duodenal internal drainage interventional treatment group, with percutaneous transhepatic gastrobiliary duodenal internal drainage after common bile ligation's 14 days, the other ( Group B , n=10 ) called control group, with only common bile duct ligation. The liver function levels including TBIL,DBIL,ALT,ALB are determined in plasma in the special time. The liver tissues were HE dyed and inspected with optical microscope. CT scan of liver was performed. Results Technical success rate was 100% in Group A. One case was died of gastrointestinal bleeding after percutaneous transhepatic gastrobiliary duodenal internal drainage therapy the list day and the complications occurred in 50%,mainly included biliary hemobilia, fever in group A. All animals died during the 23 rd to 32 nd day after common bile duct ligation in group B. The mean survival time was 28.3 days . The contents of TBIL ,DBIL, ALT continuously increased and were obviously declined after percutaneous transhepatic gastrobiliary duodenal internal drainage therapy. The liver tissue was rebuilt and inspected without biliary obstruction signs. Conclusion The percutaneoustranshepatic gastrobiliary duodenal internal drainage was quite safe and effective palliative therapy for obstructive biliary, especially refractory obstructive biliary.