| Objeeading cause of gastrointestinal ulcer. NSAIDs has been widespread used over the world and there are more andctive: The present studys show that the H.pylori infection is the l more people take it in recent years with the growing indication of NSAIDs. And as it niable to develop gastrointestinal comlication such as peptic ulcer, some patients had to abandon NSAIDs. So it has an important application value to consider the relationship in the gastrointestinal ulcer and associated complication between H.pylore infection and NSAIDs use.Methods: There was a case-control study between two groups. The peptic ulcer groups consisted with 308 peptic ulcer patients who were diagnosed with endoscopy, the non-peptic ulcer groups consisted with 2061patients. The patients of this groups were both admitted to The China-Japan Union Hospital in the some time from 2000. 6 to 2003. 12. We analyzed the difference of NSAIDs use history and the H.pylori infection status between this two groups and between the 208 patients with gastrointestinal hemorrhage and 595 ptients without gastrointestinal hemorrhage in the peptic groups. We also detected the serum CagA antibody in342 patientswho were diagnosed H.pylori infection from 2002. 1 to 2003. 12, in the hospital. We get the OR value and the 95% C.I of the exposed factor (H.pylori infection: NSAIDs use ) to peptic ulcer with mono-agent and multi-agent analysis. Result: mono-agent analysis shows the OR value is 2.84and 1.04 in gastric and duodenal ulcer patients of NSAIDs use; and the OR value is 3.99and 12.42 ingastric and duodenal ulcer patients of H.pylori infection. But with multi-agent analysis, the relationship between H.pylori infection and NSAIDs use in peptic ulcer shows the OR value is 5.95and 5.76in gastric and duodenal ulcer patients of NSAIDs use purely. The OR value of gastric ulcer is 19.09 in the patients who had the history of NSAIDs use complicating H.pylori infection, it's much higher than the add of NSAIDs use and H.pylori infection respectively purely, but the OR value of duodenal ulcer is 5.51 and 19.56 in the patients either NSAIDs use or H.pylori infection purely. The patient's OR value of duodenal ulcer who has the history of NSAIDs use and H.pylori infection is 24.50, higher than the OR value of NSAIDs use and H.pylori infection respectively purely, but is little lower than the add. The study on NSAIDs used , H.pylori infection and peptic ulcer with mono-agent analysis shows the OR value is 6.28 and 3.06 in the gastric and duodenal ulcer bleeding patients of the history of NSAIDs use indiridually , and the OR value is 0.46 and 0.21 in the gastric and duodenal ulcer bleeding patients with H.pylori infection respectivrly. But with multi-agent analysis shows the OR is 4.0 and 4.80 in bleeding gastric and duodenal ulcer patients of purely NSAIDs use, the OR is 0.57 (95% C.0.15-2.15) and 0.41(95% C.I 0.12-1.39) in bleeding gastric and duodenal ulcer patients of purely H.pylori infection; The OR value is 3.77 (95% C.I 1.00-14.15) and 0.95 (95% C.I 0.25-8.52) in bleeding gastric and duodenal patients of NSAIDs use and H.pylori infection. The study of the risk between ulcer bleeding and time of NSAIDs use finds, the OR value of suffering ulcer bleeding in occasional, temporary and long-term administrated patients is 4.01, 2.94 and 3.41 respectively. There is no significant difference in every groups. The CagA antibody in serum was checked in 342 H.pylori infected patients shows the Ratio of CagA antibody in the peptic ulcer patients is much higher than the control group.( it's 95.94%, 97.7% and 69.2% separately ). But it's no significant difference for the non-NSAIDs users and the NSAIDs users in every groups, suggested H.pylori infection of positive CagA is the major factor of peptic ulcer, and it's independent positive CagA and NSAIDs use. Conclusion: H.pylori infection and NSAIDs use can increase the risk of peptic ulcer, and NSAIDs use is in coordination with H.pylori infection in gastric ulcer morbidity, but it's not signifi...
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