| Objectives:1 The anterior segment neovascularization (NV) of central retinal vein occlusion (CRVO) generated firstly either from the pupillary margin of iris or from the angle of anterior chamber, yet there was no statistics about it in domestic. The angle neovascularization (ANV) was often missed diagnosis because of our lack of paying sufficient attention to gonioscopy, thus the best time of early treatment may be loss. Our study was to observe the occurrence of anterior segment NV and statistics the incidence of ANV, through which to provide theory evidence to pay sufficient attention to gonioscopy for ischemic CRVO patients.2 Panretinal photocoagulation (PRP) had been widely used in the treatment of ischemic CRVO,but there was still dissension on the time of performing PRP. Our study wanted to observe the extinction of NV in ischemic CRVO patients after PRP, and to provide evidence for choosing the time of performing PRP.3 Color Doppler flow imaging (CDFI) was an important mean of studying CRVO, yet there was no report about it after PRP. Through the study of this problem, we try to reinforce our cognition about CRVO and PRP.Methods:1 According to sight, fundus manifestation and FFA, CRVO patients were divided into two types: ischemic CRVO and non-ischemic CRVO. The features of ischemic CRVO identified from non-ischemic CRVO included: (1) Visual acuity: Ischemic CRVO decreased severely and usually less than 0.1, while non-ischemic CRVO decreased slightly. (2) Fundus manifestation: The hemorrhage was more, the distortion of vein was clearer, the papilloedema was more serious in ischemic CRVO than non-ischemic CRVO. Multiple cotton-wool spots could be seen in ischemic CRVO. (3) FFA: Ischemic CRVO had retinal capillary nonperfusion widely and NV, while non-ischemic CRVO had little retinal capillary nonperfusion and no NV.2 The iris and anterior chamber angle of each ischemic CRVO patient, whose course was less than six months, were examined carefully under slit lamp every two weeks, and record the occurrence of NV. 3 Treat the ischemic CRVO patients with PRP when INV/ANV occurred, and observe the extinction of NV.4 CDFI was used to quantitate diameter (D), peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of the central retinal artery (CRA) in ischemic CRVO patients before and after PRP; and to quantitate diameter (D) and maximum velocity (Vmax) of the central retinal vein (CRV). 5 The statistical comparison of the hemodynamic parameters before and after PRP was performed by paired-t test.Results:1 Among the 98 CRVO patients, there were 32 ischemic patients, including 14 men and 18 women. The ages of the 32 patients was from 52 to 76, mean 65.84±5.77. The courses of CRVO were from 6 days to 5 months, mean 64.27±37.70 days.2 Among 32 ischemic CRVO, 18(56.25%) occurred anterior segment NV. The time of occurrence was 2.5~6 months, mainly from 3 to 4 months. Among 18 anterior segment NV, 10(55.55%) occurred firstly from iris, 3(16.67%) occurred firstly from angle, and 5(27.78%) occurred simultaneously from iris and angle.3 The iris and angle were divided into four quadrants: superior, inferior, nasal and temporal. In 10 INV, there were 6 (60%) in superior quadrant, 2(20%) in temporal quadrant, 1 (10%) in nasal quadrant, 1(10%) in superior and temporal quadrant. In three ANV, there were 2(66.7%) in superior quadrant, 1(33.3%) in temporal quadrant.There were 5 patients occurred anterior segment NV simultaneously in iris and angle: One was in four quadrants iris and in superior and temporal angle; One was in superior,nasal and temporal iris and in superior angle; Two was in superior and temporal iris and superior angle; One was in superior iris and in inferior and temporal angle.4 NV didn't disappear only in one patient after PRP among 18 patients occurred INV/ANV, and in the rest 17(94.4%), NV regressed completely. NV began to regress at the 3rd day after PRP, and the time NV completely regressed was from 5 to 35 days,...
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