The Change And Clinical Significance Of Adrenomedullin And AngiotensionⅡ In Patients With Pregnancy-induced Hypertension Syndrome

Objective: To investigate the content of adrenomedullin (ADM) and AngiotensionII (AngII) in patients with Pregnancy—induced Hypertension Syndrome(PIH) , and normal late pregnant woman and not pregnant woman , in order to research the pathogenesis and clinical significance of the PIH .Methods: 1,To measured by radiommunoassay: ①The plasma ADM and AngII levels in PIH,normal late pregnant woman and not pregnant woman. ②To have used the Ligustrazini in a part of plasma ADM and AngII levels in PIH. 2,The ADM and AngII in placenta were determined by immunohistochemistry method with PIH and normal pregnant woman.Result: 1,The plasma levels of ADM in PIH groups were significantly higher in patients with normal pregnant woman groups; The plasma ADM and AngII in PIH groups and normal pregnant woman groups have notable meaning. The plasma ADM and AngII in PIH: severe>moderate>mild PIH groups. There were significantly difference in three groups (p<0.05). 2,The use of Ligustrazini in patients with PIH were notable meaning decreased from beginning to end between plasma ADM and AngII (p<0.05). 3,Not pregnant women groups and normal pregnant women groups in plasma ADM and AngII have notable meaning (p<0.05). 4,The ADM and AngII were expressed in both normal and PIH placenta. However, its level was significantly higher in the latter than in the former. The ADM and AngII were located in vascular endothelium and syncytiotrophoblast of placenta. The normal pregnancy groups and PIH groups and were notable condition with PIH (p<0.05), the express were strengthen in placenta. 5,The two groups of normal pregnancy groups and PIH groups in the plasma and placenta have the significantly positive correlation, rADM=0.79, rAngII=0.87.Conclusion: It is suggested that ADM and AngII may play a certain role in the pathophysiology of PIH. The elevated plasma AngII levels may be responsible for the rise of plasma ADM levels in patients with PIH. The placenta may be produced the ADM and AngII. The expression of ADM and AngII may be associated with the pathogenesis of PIH.