Study Of The Clinical Anti-aggregating Effect Of Picotamide On Platelet

Platelet aggregation may cause some cardiovascular diseases, including thrombosis and atherosclerosis. It is well recognized that antiplatelet therapy can effectively reduce the incidence of cardiovascular events in patients with atherothrombotic diathesis. The research of antiplatelet agents is becoming our focus.Objective: To evaluate the clinical antiplatelet effect and safety of picotamide on platelet. Methods: 48 patient with peripheral thrombosis and atherosclerosis or cardiocerebrovascular diseases were randomized allocated into following groups: picotamide group and ticlopidine group. The patients in picotamide group received treatment of picotamide 300 mg tid and the simulation of ticlopidine 1 tablet qd. The patients in ticlopidine group received treatment of ticlopidine 250 mg qd and the simulation of picotamide 3 tablets tid. Laboratory tests including ADP-induced platelet aggregation, PT, APTT, fibrinogen, blood RT, urine RT and blood biochemistry were done in the beginning and 4 weeks after treatment. Result: The platelet aggregation of every group was redued significantly incomparison to pretreatment (p<0.001). The two groups have no significance difference in platelet aggregation. In 4 weeks after treatment, the reduction of ADP (l.Oumol/L) induced platelet aggregation was 2.863?.711 in picotamide group and 3.242?.937 in ticlopidine group. The prolongation of PT and APTT and the reduction of fibrinogen in picotamide group have significance difference. In ticlopidine group, the prolongation of APTT could only be found. picotamide group have more significant effect in the reduction of fibrinogen in comparison to ticlopidine group. 1 patient in picotamide group got headache and 1 patient got stomachache during the treatment. The symptom is mild and can be reduced soon. No patient quit the test on account of adverse event. Conclusions: In our research, the clinical anti-aggregating effect of picotamide is similar to the effect of ticlopidine. The adverse events of picotamide are mild. Picotamide can be used in the prevention and treatment of cardiocerebrovascular diEN...