The Distributions Of Ganglia And Enteric Glial Cells And Interstitial Cells Of Cajal In The Congenital Intestinal Atresia

Objective: This study aims to evaluate the distribution of ganglia and enteric glial cells in congenital atresia and discuss the clinical significance. Methods: Immunohistochemical analysis of small bowel from patients with congenital intestinal atresia(n=15) and normal intestine(n=6) was performed for NT-3, Trk-C, GFAP and Nf.Results: A significantly higher proportion of myenteric plexuses neurons were NT-3 in control than small bowel atresia (t'=9.9000, p < 0.05). In the 8cm segments, NT-3 positive cells have same expression as the normal control (t= 1.2976, P > 0.05). A significantly higher proportion of myenteric plexuses were Trk-C and Nf in control than small bowel atresia. The proportion of myenteric plexus glial cells in the intestinal atresia expressed higher GFAP than control.Conclusion: There is a near total of ganglia and axonal network in myenteric plexus of congenital intestinal atresia and proliferative glial. Our results suggested that the change of myenteric plexuses in congenital intestinal atresia might be reduced pressure of intestinal volume and affected function of atretic intesine.