| Objective: To study effects of epileptic seizure on hippocampal sensory gating in rats. Methods: Epileptic model induced by Benzyl penicillin was employed in this study. Auditory evoked potentials in hippocampus were recorded after the exploring electrode was implanted in CA1 of hippocampus. Conditioning-testing paradigm (S1, S2) with 500ms interval was adopted in this study to observe changes of peak-peak size, latency, ratio of T/C of S2 and S1 N40 wave between the experimental group and control group. Results: Compared with the control group, there are no significant changes of S1 peak-peak size, latency of S1 or S2 and T/C ratio of N40 wave of the experimental group on the first day, but the S2 peak-peak size is statistical higher (P=0. 043). Within the week of repeated seizure, there is no statistical difference of electrophysiological index between the experimental group and the control group before epileptic seizure and before saline except S1 latency of the experimental group, which is longer. Compared with those of the control group, the general tendency of epileptic seizure of the experimental group after the second day included: S1 peak-peak size was statistically decreased; S1 latency had no significant changes; S2 peak-peak size and latency had no statistical changes; T/C ratio of N40 wave was augmented significantly after epileptic seizure. Conclusions: Epileptic seizure has acute and potentially chronic effects on sensory gating of hippocampus in rats.
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