| Objective: The task to prevent embolism after heart valve repalcement is always paid more attention all the while.Thrombus is induced by boring normal mechanism of blood coagalation and making some blood cell and protein actived.At last the thrombus of platelet-fibrin is formed.It is an complex proedss concluding so many kind of cell and metabolic channel and it has very close realation with hemorrheology. The drug of anti-vitaminK and anti-platele such as warfarin and asprin are applied in clinic.But they all have some side effects,for example, haemorrhage was easily brought on by warfarin. It is disputed if warfarin induces oaf at gestation. Furthermore the platele which is the main component of thrombus is not restrained by warfarin. Asprin results in a series of side effects of alimentary canal such as hemorrhage, canker,etc .Lately along with the study of salvia milliorhiza and ligusticum wallichii franch in-depth evidence for they do good to cardiovascular system become more and more.It can prevent thormbus through restraining platelet assembling. It is said that thrombus has relation with fettle of platelet assembling by Chinese iatrology.And that huoxuehuayu could restain platelet assembling, improve blood circulation and restrain platelet assembling. We supprose to select some Cinese medical herbs which has the effect of anticoafalation and cardioqi-nourishing technique. That we could make Danxiong Yiningyin (DX).Through the animal experiment choose some parameter which could reflect the anticoagalation and hemorrheology.We observe the effect of Danxiong Yiningyin in comparsion with warfarin in order to provide experimental data for the development and application of the two drugs in clinic .Methods:Choose pure bred twenty-four rabbits (2.2± 0.5kg).Divide them into four groups at radom. Every group has six rabbit.The four group include Danxiong Yiningyin low high group warfarin group and control group. The Chinese medical herbs of the root of red rooted salvia, chuanxiong, honghua,etc, provided by Hebei medical material company. Then make it into hydromel.Warfarin was made into power and mixed pured water into solution.Accroding to the weighth each rabbit take the drugs every day. Take the blood and then examine the PT,APTT at third, fifth, seventh day by appartus ACL-200(America backman).Examine the hemorrheologic at the seventh day by appartus LG-R-80 automatic blood analyzer(Beijing shidi company).Examine the rate of platelet assembling max and ELT at the seventh day too. All data was tested with spss10.0 software. Numberical variable data were wxpressed mean( stand deviation.P value<0.05 was considered statistically signifiant difference. Result: Results showed that Dxiong Yiningyin could significantly prolong PT,APTT in rabbit which take it.The third day the PT,APTT of Dxiong Yiningyin low and high group were simliar with control group.No significantly different- ce(P>0.05)showed.but That compared with warfarin group, has significantly difference(P<0.05).At fifth day the Dxiong Yiningyin low and high group.No significant difference has found in two Chinese medical herbs(P>0.05). Compared with control group It has significant difference(P<0.05).Compare with warfarin group no significant difference was observed(P>0.05).At the seventh day no significant difference has found in two Chinese medical herbs(P>0.05).Compared with control group It has significant difference(P<0.05). Compare with warfarin group, no significant difference was observed(P>0.05).Take blood to examine the hemorrheologic parameters. Whole blood viscosity, plasm viscosity and erythrocyte deformed index lowered obviously as compared with warfarin group(P<0.05). The platele Amax in the DX group was 33.29±4.72%, 25.57±3.27 % and that Compare with control group significant difference was observed(P<0.05) in ELT.Conclousion: Through the animal experiment DX could significantly prolong PT,APTT in rabbit.It illuminates that DX interfere with endogenesis and exterior approach in cruor process. DX had a mor...
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