| Abstract:Objective To investigate the protective effects of ulinastatin (UTI) on pulmonary function against ischemia-reperfusion injury in open heart surgery with cardiopulmonary bypass (CPB). Methods We collected 30 patients who underwent cardiopulmonary bypass heart operations from July, 2003 to January, 2004. Thirty patients scheduled for CPB heart operations were randomized into three groups: control group (10 patients), ulinastatin treatment group U1 (10 patients) and group U2 (10 patients). Group U1 received ulinastatin 300,000 unit given intravenously 10 min before aorta cannulation. Group U2 received another ulinastatin 300,000 unit added into the priming fluid. Control group received the same volume of normal saline instead of ulinastatin. Serum samples were collected before CPB (T1), at 10 min (T2),60 min (T3) and 240 min (T4) after CPB respectively for interleukin-6 (IL-6) and interleukin-8 (IL-8) assay by radioimmunoassay techniques. Pulmonary thoracic compliance (Cs) and dynamic compliance (Cd) and respiratory indexes (RI) were calculated at T1, T2, T3 and T4 time segment respectively. Results There were significant differences in the values of RI,Cs,IL-6 and IL-8 at T2 and T3 between the group U2 and the control group(P<0.05). There was a significant increase of Cd(P<0.01) in the group U2 compared with the control group. There were no significant differences in the values of RI,Cs,IL-6 and IL-8 at T1,T2 ,T3 and T4 between the group U1 and the control group(P<0.05). There was a significant increase of Cd (P<0.05)in the group U1 compared with the control group. The level of sera IL-6 of the group U2 at T3 was lower than that of the group U1(P<0.05). RI,Cs,Cd,IL-6 and IL-8 raised to the peak at T2 in the three groups. Conclusions Ulinastatin can protect pulmonary function after cardiopulmonary bypass heart operation and the protective effect of UTI 600,000unit was better than that of UTI 300,000unit.
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