| Artemisinin extracted from Artemisia has been shown to have strong malarial parasiticidal effect and is currently the front choice medicine when treating malaria. Products derived or resembling Artemisinin on the international market remain expensive which influences the distribution and dissemination of these products. In examining the reason for this, we see that the volume of this product extracted is low. Another important reason is that many byproducts from this extraction product, such as Artemisia naphtha and Artemisia acid, are not completely used and are generally treated as waste. This not only leads to soil and environmental pollution, but also adds to the cost of the production of products derived from Artemisia. In order to reduce the cost price of Artemisininit is of great interest to research the rate of combined use of Artemisia. Artemisia has a bitter, pungent and slightly cold nature with qi fragrance and it enters the liver and gallbladder channels. As such, it possesses clearing heat and detoxifying as well as anti-febrile characteristics. Simultaneously recent research has proven that Artemisia's volatile oils posses anti-viral and dermal fungal inhibiting properties. Clinically, when Artemisia is added to a brewed formula towards the end of the boiling process, it is able to reduce fever. As a result, there is a need to initiate research on the effect of Artemisia's volatile oils on dermal acne and bacteria as well as its anti-febrile properties.Acne vulgaris is a common and recurrent dermatological problem, with the highest occurrence for men and women in there adolescent years. It is a chronic infection of the sebaceous glands which mainly occurs on the face, chest and back appearing as a blackhead or comedo, papular eruption or exzema, and secondary pustules or nodes or cyst. Patients will often suffer from pockmarks, or hyperplastic scars which can influence the quality of their lives. The etiology of acne is thought to be related to: 1. abnormal follicular keratosis of the sebaceous gland ducts; 2. microbial influence, mainly due to propionibacterium; 3. testosterone modulation of the sebaceous glands; and 4. inflammatory damage. In Chinese medicine, this disease falls under the category of, "lung-wind fenci." Chinese medicine recognizes this problem as mostly due to poor dietary habits. Excess eating of fatty, sweet and rich foods lead to damp heat in the lungs and stomach which then results in infection of a wind-pathogen and finally acne. That this problem often affects people in their adolescence and that acne in women is more severe at the time just before their menstrual period indicates that the root of this problem is excess mutual fire. The over indulgence in spicy, fat and rich foods forming damp heat with qi and blood stagnation in the skin channels is the 'branch' manifestation.In order to investigate the effect of Artemisia oil on acne and its mechanism as well as measure its anti-febrile effect on heat induced by yeast powder through gastro-intestinal administration of Artemisia oil, we designed the following experiment:1. The preparation of Artemisia oil flexible liposomePreparation of colloid and methodology: place 2.75g of soybean lecithin, 0.75g of sodium deoxycholate acid and 1.8ml of Artemisia volatile oil into a pear-shaped beaker and add a 1:1 ratio of (chloroform: methanol) until dissolved. The dissolved solution was removed after evaporation through rotation . The lecithin formed a thin even coating along the wall of the beaker container. Then 153.9mmoml/L of NaGl solution was added to the heated beaker until reaching 20ml. This mixture was shaken and made into a coarse solution when combined with the supple liposome after which it was dissolved in ice water and given 5-10 minutes of probe ultrasound. This method allowed us to obtain the liposomal solution. Finally 153.9mmoml/L of NaCl solution was added into the heated beaker until reaching 100ml.2. Measuring the inhibitory effect of Artemisia oil and Artemisia liposome on three types of virusesWe used the in vitro medicine-media method. Results: Artemisia oil has a differing inhibitory effect on the three main types of bacteria responsible for acne. Comparatively, Artemisia oil liposome has the stronger inhibitory effect, especially for staphylococcus aureus and pityrosporum folliculitis. Thus, it is worthwhile to research further its potential use as an external application for acne and other dermal disease.3. Observations on the clinical effect of Artemisia oil liposome as a facial scrubAll patients were observed on an outpatient basis. Treatment periods lasted one month with the average observation lasting 1-3 treatment periods. Evaluation was based on the number of acne blemishes, changes in skin damage and improvements in related symptoms. 36 patients suffering from acne vulgaris were accepted into this project. Results: 8 patients were completely cured (all dermal damage completely disappeared) (22.2%), 20 patients showed significant improvement (over 75% improvement in skin damage) (55.6%), 4 patients displayed a certain effect (over 50% improvement in skin damage) (11.1%), and 4 patients had no effects (no change in skin damage) (11.1%). No discomfort or side effects were noted, however there were signs that the problem recurred following discontinuation of treatment. This showed that there was a correlation between the treatment period and the efficaciousness. While light cases should undergo one treatment, severer cases should continue treatment for at least 2 treatment periods depending on the individual circumstances.4. The anti-febrile effects of gastro-intestinally administered Artemisia oil on dry-yeast induced fever.We selected 24 rats which were randomly divided into 4 groups of 6 rats each. They were all weighed. 3 days prior to the experiment, their rectal temperatures were taken twice with acceptable body temperatures below 38.3 °C (typical rat body temperatures average 36.6-38.3 °C) Rectal temperatures taken on the day of the experiment were all measured at below 38.3°C. Then, a 20% solution at lOml/kg of dry yeast was subcutaneously injected into the backs of the rats. After 6 hours, body temperatures reached a peak (average temperatures rose 1.2 to 2.2 °C) at which time we began administering medicine: 1) A... |
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