Clinical Observation Of Tumor Patients On Phase Ⅱ With Depolarizing Neuromuscular Blocking Drugs

Objective:To investigate the clininal problem of tumor patients during operation:to observe the occurrence of phase II block and to study the effect on recovery of muscular relaxant with acetyl-cholinesterase inhibitor. Methods:26 hospitalized tumor patients were randomly divided into two group:Group A accepted 1.5mg/kg and Group B accepted 1mg/kg suc-cinylcholine respectively during induction of anesthesia ,then continous 0.1% succinylcholine infusion to maintain muscular relaxant.Ulnar nerve was stimulated with train-of-four(interval=12sec,frequency=2Hz) via surface elec- trodes at the wrist. The TOF was used to monitoring of neuromuscular function.antagonism of a phase II block.The Group A patients of phase II block was antagonized by a cholinesterase inhibitor (neostigmine) . Results:The patients of TOF fade during induction of anesthesia were not statistically significantly different.The recovery time of train-of-four in patients of phase II block with acetyl-cholinesterase inhibitor was significantly short. Conclusion:The tumor patients with depolarizing neuromuscular blocking drugs during induction of anesthesia had a higher rate of train-of-four (91.67%).The rate of phase II block during recovery of anesthesia was 96.15%. antagonism of residual phase II block was successful .