The Dose-response Effect Of Surfactant Replacement On Pulmonary Gas Exchange In Rabbit With Acute Lung Injury Induced By HCl

Department of Anesthesiology, First Affiliated Hospital of Nanjing Medical UniversityObjective: To evaluate the dose-response effect of surfactant replacement on pulmonary gas exchange in rabbit HCl-induced lung injury.Methods: After the rabbit was anesthetized and mechanically ventilated via tracheotomy, lung injury was then induced in rabbits via intratracheal injection of 0.0225N hydrochloric acid (12 ml/kg). Followed by a period of 1h controlled ventilation(CV), the animals with PaO2/FiO₂<=150mmHg were then randomized into five groups with five animals each. Lung lavage was then performed with saline in the group one; pulmonary surfactant of 1g/L in the group two; pulmonary surfactant of 3g/L in the group three; pulmonary surfactant of 6g/L in the group four; pulmonary surfactant of 12g/L in the group five.Results: PaO₂/FiO₂ increased to about 350mmHg in group three, group four and group five after lung lavage, which sustained only for 3 hours. PaCO₂ decreased a little in group three, group four and group five, but not sustained for 2 h .As to PIP, it only decreased in...