Vector Construction And Expression Of CLC3 Gene-targetting SiRNA Vector And Its Proliferation Effect On Tumor Cells

Chloride is the most abundant anion in extracellular fluids. Chloride channels, tansmembrane proteins, which balance chloride, play a critical role in numerous physiological functions. Electrophysiological studies have demonstrated the existence of numerous types of anion channels cells. CLC3 is one of these channels. CLC3 is widely expressed in many kind of tissues, including brain, liver, and kidney, et al. Some evidence reveals that CLC3 gene codes VORC. However, several researchers hold against this standpoint. Furthermore, there are experiments confirming that CLC3 is overexpressed in tumor cells including stomach neoplasm. This suggests that CLC3 plays an important role in cell cycle and cancer metastasis.