Correlation Study Of Carotid Arteriosclerosis With Acute Ischemic Cerebrovascular Events By Ultrasonography

Objective:To evaluate whether extracramal carotid structure abnormalily(carotid atherosclerosis) measured by duplex ultrasonography is related to cerebrovascular risk factors and ischemic cerebrovascular events. And investigator hope that it can make flexible cross-combination of these syndrome factors when they make syndrome differentiation in their clinic practice, the authors of this inverstige hope that it can provide a new approach for the diagnosis of TCM Syndromes of Apoplexy.Methods:Although the syndrome differentiation and the treatment according to the differentiated syndromes are the clinical traditional Chinese medicine (TCM), both the terms for differentiated syndromes and the classification ofthe differentiated syndromes need to be standardized, up to now, the diagnostic system of TCM syndromes is a complicated nonlinear macrosystem. Group of the Diagnostic Standardization of TCM Syndromes of Apoplexy have been used in clinic. Professor Wang Yong Yan had raised the following hypothesis: by a decomposition and analysis method, 29 syndromes factors can be extracted from the six major categoriesOf TCM syndromes, namely, the syndromesdue to the six exopathogens,Syndromes due to the five endogenous pathogens, syndromes related to qi, syndromes related to related to the blood, syndromes related to related to yin and yang, and the syndromes related to other pathogens.So this investigation extracted some syndromic factors to compose four syndrome: the syndrome of accumulation of phlegm and blood stasis group;the syndrome of hotness group; the syndrome of deficiency group and the syndrome of wind group.Sonographic assessment of the extracranial carotid atherosclerosis (AS) was performed by using a duplex ultrasound system .According the result ofthe carotid artery ' s color doppler ultrasound, to separate acute cerebral infarction patients into 4 group: carotid arteriostenosis group, carotid atherosclerotic plaque group> a little carotid atherosclerosis group, common carotid arterygroup. Carotid atherosclerosis, common carotid artery intimal-medial thickess (IMT), narrowing of the carotid arteries, and all the character of the plaque, the endodermis were assessed by 7.5-MHZ duplex ultrasonography. All the patients Comparison analysis were performed. 41 transient ischemic attack and 82 controls subjects without cerebrovascular diseases were imagedThe results of data were expressed by x ±s and analysed statistically by using a SPSS 10.0 package.Results:In all of the acute stroke patients the percent of the syndrome of wind, the syndrome of accumulation of phlegm and blood stasis; the syndrome of hotness and the syndrome of deficiency were 72. 0%, 68. 4%, 47. 2% and 26. 4%.The prevalence of carotid atheroscalerosis in Acute Ischemic Cerebrovascular events were 90.4% respectively. The rate of CAS in patients with cerebral infarction is significantly higher than common carotid artery group The distributing of the result of the carotid artery' color Doppler ultrasound are significantly difference (P<0.05).he incidence of carotid artery of stenosis and the carotid atherosclerosis were significantly higher in the hotness sign group and the syndrome of accumulation of phlegm and blood stasis group than in the non-hotness sign group and non-accumulation of phlegm and blood stasis .IMT thickenings were significantly higher in the syndrome of accumulation of phlegm and blood stasis group than in the non-accumulation of phlegm and blood stasis (P<0.05).Correlation analysis showed thatcarotid atherosclerosis of endodermis were associated with the hotness sign group and the syndrome of accumulation of phlegm and blood stasis sign group. Logistic regression analysis identified 4 significant variables that accounted for the syndrome of accumulation of phlegm and blood stasis group, they were IMT, RI, Carotid atherosclerosis and the Character of endodermis.Conclusion: the hotness sign group and the syndrome of accumulation of phlegm and blood stasis sign group were closely related to the carotid atherosclerosis , especially the syndrome of accumulation of phlegm and blood...