| Objective The aim of this study was to investigate the changes of peripheral plasma of oxygen free radicals: Maleic Dialdehyde( MDA) , Superoxide Dismutase (SOD) , Glutathione Peroxidase (GSH-PX) , VitaminC(VC), VitaminE(VE) in severe acute pancreatitis (SAP)patients with acute lung injury(ALI), to discuse the possibility and the clinical significance of the mechanisms of releace-eleminate of the oxygen free radicals, and foul-up of the peroxidation-antioxygen. Methods Using the colorimetry method, the MDA and SOD and GSH-PX and VC and VE were examined in the peripheral plasma of the 22 SAP&ALI patients and 30 controls. Results The level of MDA in SAP patients with ALI was 10. 41 ± 1. 57nmol/ml, the controls was 4. 26 ± 0. 59 nmol/ml, The level of MDA in SAP patients with ALI was higher than the control' s (t=6. 725, p<0.001), The level of SOD in SAP patients with ALI wasl492. 61±139. 72.u/ml ,the controls was 1959. 67 ± 173. 47u/ml, The level of SOD in SAP patients with ALI was lower than the control' s ( t=7.514, p<0. 001) , The level of GSH-PX in SAP was 0. 96 ± 0.17nmol/ml, the controls was 2. 01 ± 0. 42nmol/ml, The level of GSH-PX in SAP was lower than the control' s (t=6. 398, p<0. 001) , The level of VC in SAP patients was 28. 67 ± 6. 94umol/L, the controls was60. 29 ± 10. 84 umol/L, The level of VC in SAP patients was lower than the control' s( t=7.125, p<0. 001), The level of VE in SAP patients with ALI wasl8.17 ± 2. 96umol/L, the controls was26.14 ± 5.17 umol/L, The level of VE in SAP patients with ALI was lower than the control' s(t=5. 267, p<0. 001). Conclusion The peroxidative injury might participate in the development of SAP with pulmonary injury.
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