The Relation Between Coronary Heart Disease And Matrix Metalloproteinase-9,Tissue Inhibitors Of Matris Metalloproteinase-1

Objective To investigate the relationship between serum level of matrix metalloproteases-9 (MMP-9), tissue inhibitors of matris metalloproteinase-1 (TIMP-1) and coronary atherosclerotic plaque rupture, and the correlations between MMP-9,TIMP-1 and the degrees of coronary artery lesion .Further understand the function of MMP-9 and TIMP-1 in coronary artery atherosclerosis. Methods There were 42 patients with acute coronary syndrome (ACS) ,29 patients with stable angina pectoris (SAP), and 25 healthy controls; ACS included one subgroup which had 21 patients with unstable angina pectoris. At the same time, the serum levels of MMP-9 , TIMP-1 measured by sandwich enzyme immunoassay technique were compared among all groups. The jeopardy score for coronary artery lesion was evaluated according to the method by Califf. Results The serum level of MMP-9 in ACS group was higher than that in SAP group (P<0.01) and control group (P<0.01) , and the serum level of MMP-9 in SAP group was higher than that in control group (P<0.01) ,while the serum level of TIMP-1 in ACS group was lower than that in SAP group (P<0.01) and control (P<0.01) . There was significant difference in serum level of MMP-9 and TIMP-1 between ACS, SAP, and control group. MMP-9 showed a positive correlation with jeopardy scores, while TIMP-1 showed a negative correlation with jeopardy scores. Conclusion Plaque rupture is related to the increase of the serum level of MMP-9 and the decrease of the serum level of TIMP-1; which can be regarded as a serum mark of plaque rupture. The increase of serum MMP-9 and decrease of TIMP-1 may better describe the degrees of coronary artery lesion, and evaluate the prognosis of patients with coronary heart diseases.