| Object: To explore new preventing and cure method of cerebrovascular disease and preventive mechanism on ischemic cerebral apoplexy of moxibustion.Methods: moxibustion before brain ischemia in four vessels occlusion(4-vo) model rats. After ischemia, to detect Bcl-2 Bax protein expression.Results :â‘ Bcl-2 protein expression increased significantly after moxibustion preconditioning, the peak appeared ahead of time which was remarkable differences comparied with ischemic group. â‘¡ As comparied with brain ischemic preconditioning group bax protein expression wasn't remarkable .Conclusions: pre-moxibustion has preventive effect on neuron of ischemic hippocampal CA1 section. Moxibustion preconditioning can prevent apoptosis of brain ischemia by increasing Bcl-2 protein expression. Pre-moxibustion acting as a method of BIP, can induce brain ischemic tolerance and lighten neural damage of ischemic cerebrovascular disease.
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