The Influence Of Physical And Chemical Properties On Bioactivity Of Treated Titanium Surface

The materials that can take biochemistry react with organism tissue are bioactive materials. They can connect with tissues by chemical bonding which formed through physical and chemical reaction. This bonding is continuously in interface structure and function under molecular size.Early research indicated that titanium surface can formed a bone-like apatite layer after surface modification in biological environment. This kind of mental containing bone-like apatite layer is called bioactive mental.Recent study proved that the thickness, microstructure, chemistry composition of oxide film can affected the biological corrosion-resistance ability, hydrophile property and bioactive macro molecule absorption, then affected the biocompatibility and the match process in the body.The surface of titanium has a layer of dense TiO₂. After being treated with specially method, a chemical bonding can be formed between titanium and bone. Usually we consider that the TiO)2-gel enrich of Ti—OH does a important role in this process. Currently, the study of titanium surface modification is mainly focus on add apatite coating onto titanium directly or make bioactive TiO₂-gel layer.We took the methods of alkali treated, alkali-heated treated and acid-alkali treated, acid-alkali-heated treated to modify titanium surface; analyzed the stability of TiO₂-Vgel, the micro structure of TiO₂ layer, chemistry composition and the infections of all these factors to apatite formation process. Furthermore, we used MTT to investigate osteoblast's differentiation on different surface.The result indicated that, the surface of both alkali treated titanium and acid-alkali treated titanium formed TiO₂-gel layer. After heating at a temperature of 600°C for two hours, this layer crystallized and TiO₂ turn into rutile phase.We investigated the apatite formation ability of different surface through simulated body fluid (SBF), proved that the stability of TiO2-gel, crystallized T1O2 and the porous structure had advantageous to promote the apatite formation.The biological evaluation on different treated titanium surface show us that all the materials after bioactive treatment had a good biocompatibility, and can promote the differentiation of osteoblast. Further more, we found porous structure is benefit for osteoblast to attach with.