Investigation And Analysis Of Popular Current Situation And CD₄～+,CD₈～+ T Lymphocyte Level Of Some Place HIV/AIDS Of Henan Province

Objective: To understand the popular situation of some place HIV/AIDS of Henan province. Analyze CD4+, CD8+ T lymphocyte level of HIV/AIDS. Probe into the standard according to what the case is selected to take part in the anti-virus treatment, Provide scientific basisfor clinical treatment.Methods: Describe epidemiology is analyzed to Henan Province someplace 1995-2004 all 2990 HIV-positive authenticator's materials. Vein blood CD4+, CD8+ T lymphocyte is measured to 2335 HIV/AIDS patient surviving now. Understand its immune state. And compared CD4+ T lymphocyte count and CD4+ / CD8+ T lymphocyte ratio between HIV/AIDS patient and normal person, the infected of HIV and AIDS patients now. Find the relationship between CD4+ T lymphocyte counts, CD4+/CD8+ T lymphocyte ratio and disease process. Calculate sensitivity, specificity, Youden index, positive predictive value, and negative predictive value. Probe into the standard according to what the case is selected to take part in the anti-virus treatment.Results: ① There were the following characteristic in this place HIV/AIDS popularity in 1995~ 2004: ② HIV/AIDS epidemic situation distribute range to be wide, there were the infected of HIV in the whole city 13 counties (city, district), some areas appeared high degree of concentration. (2) Man exceed women, the infected of women strengthenthe potential dangerous of mother-to-baby transmission.③The infected rely mainly on married and between twenty and fifty. Influence the labor productive forces directly, Cause the decline of the social economic development level and a great deal of other social concerns, and have increased the danger that HIV transmits through sex. ④The infected take the overwhelming majority with peasants with less schooling. The countryside lacks monitors and enough health facilities and medical treatment ensure, the population schooling is on the low side, protect consciousness force peasant to be easy to infect HIV, even easy to pass the virus to own household. ⑤ HIV infect way appeared pluralistic trend, And already appeared from high-risk group (paid blood donor previously ) to general diffusion of crowd, The transmission-way have already turned into through blood , sex , mother-to- baby three kinds of ways coexist from single blood collecting and supplying infect. (2)The mean value of CD4+ T lymphocyte cell count of HIV/AIDS of this place was only 310.58/ul. They were all significantly lower than normal population (P<0.01). This testing result conformed with this place basically, around 1995, because the behavior of illegal and substandard blood (thick liquid) collecting and supplying caused a large number of the infected of HIV, since 2001, begin to present AIDS case concentrating on having illness coming on and death. (3)The CD4+ T lymphocyte count, CD4+/ CD8+ T lymphocyte ratio in the blood in periphery obviously relevant with HIV/AIDS disease process. The difference between different age group of HIV/AIDS patient vein blood CD4+ T lymphocyte count have remarkable meaning (P<0.01); Age natural logarithm and CD4+ T lymphocyte count have dependence.(4)Though CD4+ T lymphocyte count and CD4+/ CD8+ T lymphocyte ratio have direct relation with HIV/AIDS disease process, But analysis to its sensitivity, specificity, Youden index, positive predictive value and negative predictive value,etc. Finding Henan Province current AIDS anti-virus treatment selected standard CD4+T lymphocyte count <200 /μl (not have lower limit) have higher peculiar degree (68. 78%), but the sensitivity is lower (47. 55%); Use CD4+/ CD8+ T lymphocyte ratio <1. 00 screen into the example of curing the disease, its sensitivity is higher (95. 80%), but peculiar to be the low in degree (only7.56%).Conclusions: (1)This place HIV/AIDS situation is severe , should pay special attention to AIDS preventing and controlling . (2) The immune level in this place HIV/AIDS patient is low, face having illness coming on and death peak. (3) CD4+ T lymphocyte count and CD4+/ CD8+ T lymphocyte ratio are good indexes reflecting HIV/AIDS diseases of process. But while treating the index as selected anti-virus, can't use these two indexes simply, and should combine clinical manifestation to consider synthetically.