The Application Study Of Middle-field Magnetization Transfer Imaging Of Tumor And Tumor-like Lesions In Brain

Objective: To investigate the application value of middle-fieldMagnetization transfer imaging of tumor and tumor-like lesions inbrain.Materials and methods: The conventional MR imaging and SE ,3DSPGR sequences with and without MT pulse were performed in 20 casesof benign neoplasms ,26 cases of malignant neoplasms and 10 casesof tumor-like lesions(histopathology verified or clinical following-upconfirmed) before operation and clinical cure, including 24 necroticor cystic cases (34 lesions),and also 36 cases with enhanced T1WI,SE-MTI,3DSPGR-MTI were included. The values of which measuring orcalculating from all sequences were processed and statisticalanalyses were performed by using the software of SPSS11.0.Results: The C and C/Ns values of SE-MTI were the lowest among thefour Unenhanced sequences, and the C value of T₂WI was the highestthan that of other three sequences(p﹤0.001),however, the C/Ns valueof 3DSPGR-MTI was higher than that of T2WI( p=0.335) and T₁WI,SE-MTI(p﹤0.001);For three enhanced sequences, 3DSPGR-MTI had thehighest C/Ns value, the second SE-MTI, the third T₁WI(p﹤0.001among them),and the C values of 3DSPGR-MTI and SE-MTI were almostsame ,both of which were higher than that of T₁WI(p valuewas 0.016,0.003 respectively).The SEMTR and 3DSPGRMTR of solidparts among benign ,malignant and tumor-like lesions had nostatistical difference each other, however, necrotic area ofabscesses had significant higher SEMTR,3DSPGRMTR than necrotic orcystic area of glioma and metastasis (p﹤0.001), and there was nodifference between necrotic or cystic area of glioma and metastasis(p>0.20).Conclusion: Enhanced 3DSPGR-MTI might be the substitutefor conventional Enhanced T1WI,the measurement of its MTRwas helpful in differentiating brain abscess from necrotic orcystic tumors on middle field,and was an important supplementary forroutine MRI.