Study Of Pathology Of Thyroid Arterial Embolisation To Treat Hyperthyroidism Caused By Graves' Disease

Objective To study histopathology of thyroid tissues and the relation between change of thyroid tissues and thyroid auto-antibody after thyroid arterial embolisation to treat hyperthyroidism caused by Graves' disease through observed change of histopathology and thyroid auto-antibody of patients of Graves' disease in 3 years after thyroid arterial embolisation. Materials and Methods 1 .Thirty-seven patients of Graves' disease treated through transcathter arterial embolisation had been observed through TT3 TT4 PT3, FT4 rT3. TSH TGAb TMAb, TRAb in their blood serum and color Doppler ultrasound respectively at different period (before arterial embolisation and 7 day 6 month, 3 year after arterial embolisation) .2. 22patients were underwent needle aspiration biopsy of the thyroid gland: 7 cases 2 case , 6 cases 7 cases respectively before thyroid arterial embolisation, 7 day, 6month, 3 year after thyroid arterial embolisation. Results Volume of thyroid gland shortly dwindled in size after thyroid arterial embolisation or in a few days after thyroid arterial embolisation. Dwindled thyroid gland can be observed by color Dopplerultrasound and dwindled extent of thyroid gland were not equality in the whole gland. There were small ischemia sections on background of trauma of gland tissue and ischemia after thyroid arterial embolisation. There were a few blood enrichment spots on background of ischemia. The change of histopathology were different with different case at the same period. The change of histopathology mainly showed acuted infarction 7 days after thyroid arterial embolisation ,fibrous hyperplasia 6 months because of lack of blood after thyroid arterial embolisation and mesenchyma hyperplasia and follicle atrophy 3 years after thyroid arterial embolisation. TGAb TMAb in 3 year after thyroid arterial embolisation group were high than before thyroid arterial embolisation group. FT3 FT4 TRAb in 6 month after thyroid arterial embolisation group were low than 3 year after thyroid arterial embolisation group. Conclusion Histopathology is transformation process of acute infarction fibrous hyperplasia follicle atrophy a few follicle hyperplasia encapsulated fibrous. Maladjustment of immunity of GD patients had been improved through the treat of thyr.oid arterial embolisation. Improvement of maladjustment of immunity consistent with the change histopathology after thyroid arterial embolisation, and it indicated that the pathology groundwork of state of GD was controlled in steady state in mid-term and long-term by the treat of thyroid arterial embolisation.