The Comperation Of The Effect Of Using Different Dosage Of Somatostin On Treatment The Bleeding Caused By Rupture Of Esophageal And Gastric Varices

Objective:Acute bleeding of esophageal variceal episodes(ABOVE) is a familiar syndrome in the patient of hepatocirrhosis.The most familiar causation of the bleeding is the rupture ofesophageal and gastric varices, which is caused with the highpressure of portal vein. The bleeding is almost all serious in thesepatients, so it is difficult to treat. In the past we used Pituitrin to treatacute bleeding of esophageal variceal episodes. Almost 50 percentpatients can be cured. But we did not usually use it now because ithas a lot of sideeffects. Now, we use the somatostatin to treat acutebleeding of esophageal variceal episodes. Almost 70-80 percentspatients can be cured. A lot of literatures showed that somatostatinhas better effect and fewer sideeffects than Pituitrin. Butsomatostatin is very expensive and it's dosage is so big, many poorpatients can not use it. Many clinical study on treatment of acutebleeding of esophageal variceal episodes with small dosage ofsomatostatin showed that the effect of small dosage of somatostatinhas no difference with the general dosage. On the other side ,in clinicwe also can see many patients are so serious that we can not curethem with the general dosage. Many clinical study on treatment ofacute bleeding of esophageal variceal episodes with double dosageof somatostatin in overseas showed that double dosage ofsomatostatin has better effective than the general dosage. But in ourcountry, some clinical study showed that double dosage ofsomatostatin has the same effective than the general dosage. In thisarticle we investigate the effect of different dosage of somatostatinesophageal varieal bleeding. Methods 153 cases were randomly divided into three groups; A,B, andC, patients in three groups received an intravenous injection of0.1mg somatostatin at a constant speed of 0.05mg/h, 0.025mg/h,0.015mg/h for 48 hours in groupA, B, and C respectively. It will beobservered stopping hemorrhage at 6 hours, 12 hours, 24 hours, 48hours. Rbleeding after stopped manipulation at 7 days and occurringthe side-effects. Results: 6 hours hemostasis rate were respectively 46.6%,30.6% and 30.4%. 48 hours hemostasis rate were 96.5%, 89% and86.5% (PA,B <0.05), (PB,C>0.05). Rebleeding rates were3.4%, 4.1%,and 4.3%. So our study showed that double dosage of somatostatinhas better effective than the general dosage on the treatment of acutebleeding of esophageal variceal episodes, and our study also showedthat the effect of small dosage of somatostatin has no difference withthe general dosage on treatment of acute bleeding of esophagealvariceal episodes with small dosage of somatostatin. Conclusion: Somatostatin on treatment of acute bleeding ofesophageal variceal episodes is safe, speedy. It has good-effect andfew side-effect. double dosage of somatostatin has better effective...