Study Of Tomographics And Cognitive Impairment And Insulin In Silent Cerebral Infarction

With the development of tomographics ,included CT and MRI,many SCIpatients were discovered. More and more studies appeared about SCI with theincreasing of incidence.SCI patients have not significant clinical symptom andat the same time which have not caused enough appreciation,but which cancause or aggravate cognitive funcition impairment,and which have probabilityof developing to vascular dementia,so in recently studies about SCI areincreasing gradually.Asymptomatic cerebral infarction is alse named silent cerebral infarction,which demonstrates normal adult haven't the history of vasculardisease,and isnormal in neurol system measure,but can be seen abnormal impairment ofcerebral vessel region in brain computered temography(CT) or magneticresonance imaging(MRI).It also included irresponsible lesion in the cause ofthe first stroke onset,and some small transient inspecial symptom andsyndrome also be included if there are lesion in CT or MRI ,eg dazzy,nume,and so on. Many author record the incidence of SCI respectively,and ,but theincidence of SCI strongly increase with age undoubtedly.SCI and cerebralinfarction(CI) are ischemic cerebral vascular disease,so the risk factors of SCIand CI is Related firmly. Aging,hypertention,diabetes mellitus,cornery heartdisease, cholesterol,and so on,are their common surely risk factors.There aresome reports in broad that homocysteine level and hyperinsulinemia are riskfactor of SCI.At the same time SCI is a predisposing condition for clinicallyovert stroke,which may be a risk factor for cognitive impairment.Themechanism of SCI is embolism and lacunar. Temography location of SCI inCT or MRI is in basal ganglia,corona radiate and centrum semiovale,and thelesion mostely is lacunar infarct. The risk factors of SCI and CI are the sameoverall,Aging,hypertention, diabetes mellitus,cornery heart disease,cholesterol,and so on,are their common surely risk factors.There are somereports in abroad that homocysteine level and hyperinsulinemia are probablyrisk factor of SCI. Temography location of SCI in CT or MRI is most mainlyin basal ganglia,,and the lesion mostely is lacunar infarct. Some studies shownMCI can cause or aggravate cognitive funcition impairment,and Cognitiveimpairment of SCI has association with location and number of lesion. In order to study temography charecterization and mild cognitiveimpairment(MCI) and serum insulin level of SCI,so that strengthen onrecoginition in SCI clinically, All subject diagosised by CT or MRI were testedcognitive function with MMSE and CDR,and all subjects were examined fastGlu,blood fat,and Fins.At the same time tomographics characters wereanalysised ,so that to make warranty for clinical work. we select 65 SCI patients (SCI group),and 50 matched cerebral infarctionwith lacuna infarction(CI group),and 50 normal control,and all patient comefrom residents and policlinic patients from June,2003 to December,2004 at thedepartment of neurology in China Japan Union Hospital of JilinUniversity.Meanwhile we record the lesion's location and mumber.We test allsubject cognitive function with MMSE and CDR.,and examine FGlu andblood fat by automatic analyzing machine and examine FIns by radiaimmunity.The result shown temography location of SCI is mainly in basal ganglia,next isbrain leb,cerebella, brain stem, and are all lacuar infarcts ,and mutiple SCIsand one SCI are all very common. The incidence of Cognitive impairment inSCI group and CI group is significantly higher than in normal control group.There was no significant difference in profile between SCI and CI groups. Thepatients of SCI group were shown that the ability of memory and calcilatewas slightly decreased,which are expression of MCI. Cognitive impairment ofSCI patients has association with location and number of lesion, an theincidence of cognitive impairment in double lesions and left lesions washigher than in right lesions,at the same time the incidence of it in mutiplelesions was higher than in single lesion, which demonstrated double lesionsand left lesions are more easily than right lesions in the cause of developingmild cognitive impairment,and multiple lesions are more easily than singlelesion in the cause of developing mild cognitive impairment. TG,CHO,LDL-Clevels in SCI group and CI group is significantly higher than those in normalcontrol group,particularly significant in LDL-C level,and there was nosignificant difference in profile between SCI and CI groups. Mild cognitve impairment(MCI) is a transitional stage between normalaging and dementia.It is very importment to recognize the stage ,becauae wecan distinguish the man which may become very easily dementia from oldman, so that we can adopt to preventing measure.Some authosr also think thatMCI may be dementia's especially early stage or transitional stage. Definitionof MCI can be classified to twice:one is mostly memory impairment,the otheris except memory impairment,including nitice and language,and so on.SCIpatients were mainly shown that ability of memory and calculation slightlydecreased,but who had not significant language impairment,correspondingPeterson's diagnose standard about MCI. Hyperinsulinemia and insulin resistance were shown to be independent...