| Background: Fluid therapy is a cornerstone in clinical work and is commonly used. Current guidelines for fluid therapy are, however, based on experience, rule of thumb, such as restoration of physiological parameters, which do not directly represent the volume effect of the fluid. Many efforts have been made to measure the actual volume effect of different fluids. The methods used are mainly based on isotope labeling of substances. Such a method has two inherent limitations. One is that labeling of substances results in volume estimations from the dispersal of the substance in the same space. The second limitation is the use of backward extrapolation to estimate the volume that the tracer substance that was dispersed in at time zero, leading to a single estimation for each labeled substance infused. Such a method is not suited for dynamic analysis of fluid volume dispersal and elimination, whereas volume kinetics provides a time resolution. Now, we apply volume kinetics in studing the distribution transportion and elimination of fluid in body.Object: To study the volume kinetics on the stress reaction of cardiac function and blood kinetics using voluven to expand volume in healthy people.Methods: The thesis is based on the analysis of serial measurements of blood hemoglobin concentration in conjunction with intravenous fluid infusion. The body weights of the patients, were obtained from the measurements in the morning of experiment. Then the infusion of voluven were administratedmonitoring by Bioz.com system which is the noninvasive hemodynamic and cardiac function monitoring system where voluven was given by constant rate i.v. infusion over 30min. The venous blood samples were collected for the measurements of blood haemoglobin concentration .The number of time were 8(0,30,60,90,120,150,180,240min after ^ne sjart of infusion). For every parametercombination^ data sets were simulated and fitted.Result: The infusion dose(30 ml-kg"1) given by constant rate i.v. infusion over 60min was associated with mild symptoms in all volunteers. Subjects reported a sense of swelling around the neck (n=6), in the leg (n=6), in the chest (n=3), in the abdominal (n=l). Occasional complaints of "feeling swollen" were noted during a few other experiments, but these symptoms were mild disappeared after 30min finished. The body weight of volunteers is different result in variant infusion rate.When we cope with the number of data points used in fitting the function, the optimal curve fit according to the two-volume model (V0FS1). The outcome indicate that the minimum target volume is 3702.58ml; the maximum is 8615.58ml. The VOFS2 summed volumes(Vi+V2) are significantly different from blood volume and V (P<0.01). However, the blood volume is the same with V(P>0.05). According to it. We can drive a conclusion that voluven major in distributing blood plasma after infusion.The monitoring of noninvasive blood dynamics and cardiac function imply that cardiac index(CI),cardiac acceleration index(ACI), product of heart rate and systolic pressure(HRR) and left cardiac work index(LCWI),increased with the rise of infusion volume and infusion rate. After infusing, it decreased quickly. On the contrary, the systemic vascular resistance reduce with the infusion velocity. In addition, the thorac fluid content decrease with the volume of administration...
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