Expression Of Testicular TGF-β1 In Varicoce Rats And Influence Of Shengjing-soluble Granule To TGF-β1 Expression

Objective: To prove TGFβ1 expression in varicocele rats testis. To discuss influence of Sengjing-soluable-granules to testicular TGF β1 expression in varicocele rats. Then discuss and reveal molecular level. Methods: Experimental varicocele was created in male rats by partial ligation of left renal vein .The study were divided into 3 groups randomly: varicocele group(VG), shan operation group(SOG), treatment group(varicocele+chinesetraditional medicine group VMG).The histology was observed at the 3rd postoperaative month.Results: Et was found that(l) the left testicular weight in VG was far lower than that in SOG(p<0.001). (2) the pathologic changes in VG were severer than that in VMG. (3)Amount of TGF β 1 positive leydig cell decreased in varicocele testicular tissue on the whole .most of leydig cell showed TGF β1 intensely positive in VMG rats testis. Conclusions: According to the experimentconfirmed that soluble granules of Shengjing protected can protect the testicular tissues of varicocele rats and alleviate testicular pathologic damage ; The amount of TGF β1 expression decreased in varicocele rats testis.