| The clinic research on the changes of venous outflowin patients with acute strokeObjective: To provide the clinic data for prevention of deep vein thrombosis(DVT) the state of venous outflow and venous valvalar function investigated in patients after stroke .Methods: According to the limbs paralytic degree , 147 patients were divided into two groups: group 1 in which whose limbs paralytic degree are below or equal of 3 degrees and group2 in which whose limbs paralytic degree are above of >3 degrees. A control group was consisted of 20 age-matched volunteers with normal muscle power .The The pulse volume recorder(PVR) was used for detecting Maximum Venous Outflow(MVO) on the 7th-10th days in all patients. MVO detected with PVR was compared between the patient heathy leg and his paralytic leg respectively, so did between the heathy leg of stroke group and the control group, and between different age groups.Sixty limbs in 30 patients were examined by photoplethysmography(PPG )as the assessment of venous valvular function.The level of the D-dimer of patients with stroke on the 2th and 7th day in the hospital were detected.Results: (1) compared with the MVO of self healthy limbs ,the MVO of those in group 1 in which whose limbs paralysis degree are below or equal of 3 degrees were significantly decreased, (p<0.01); but the MVO of group2 in which whose limbs paralysis degree are above of 3 degrees were not significantly declined compared with the MVO of self healthy limbs, (p>0.05); There was no difference in the MVO of healthy limbs between the patients group and controls (p>0.05). (2) The MVO of healthy limbs in patients group did not show obvious change among different age groups. (3)One patient in the stroke group with severely limb MVO below 50% was diagnotised definitedly as deep venous thrombosis by Duplex. (4)There were no difference of the VRT between the paralytic limbs and healthy limbs, and the VRT were above 25 seconds in both paralytic limbs and healthy limbs. (5)On the 2th day, the D-dimer level were higher in patients with cerebral infarction than those with intracerebral hemorrhage, On the 7th day, the D-dimer level decreased or came back to the normal level.Conclusions: On the 7-10 day after the stroke, the prevalence of deep vein thrombosis was less than 1% among the patients. In the group 1 in which whose limbs paralysis degree are below or equal of 3 degrees, thevenous outflow decrease but In the group2 in which whose limbs paralysis degree are above of 3 degrees, there is no change. Age also has no influence on the venous outflow. This suggested us to strengthen the passive sports to improve venous outflow of the severe paralytic limbs.Part IIThe clinic research on the influencing factors for the venous outflow after strokeObjective: To investigate the affection of age, hypertension ,diabeles mellitus, cholesterol, glycerinate ,fibrin and vWF on the venous outflow after stroke and to provide information for the prevention of DVT.Methods: The diagnosed stroke patients were divided into two parts: groupl in which whose limbs paralytic degree are below or equal of 3 degrees and group2 in which whose limbs paralytic degree are above of >3 degrees. The Mest or x 2-test for independent groups was used to compare the difference between groupl and group 2 of the above factors; Partial correlation analysis was used to estimate the relationship between the above factors and the MVO ; Logistic regression was used to analyze the relationship among the MVO and hypertension, diabeles mellitus , vWF and muscle power.Results: For each factor, there is no obvious difference between each two groups; There were negative correlation between the levels of plasma vWFand MVO,(r= ~ O.2428,/M).O2); hypertension and muscle power have affections on MVO, and have statistically significant (r=6.6033, r= 1.6405).Conclusion: Among all the factors we detected for the venous outflow after stroke, hypertension, muscle power and vWF have influence on MVO.
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