The Significance Of The Expressions Of Tumor-Suppressor Genes PTEN, P16 And Oncogenes Bcl-2, C-myc In NGM, CAG (GEDâ… -â…¡), CAG(GEDâ…¢) And GC

Objectives To investigate the expressions of PTEN, P16 protein and Bcl-2, C-myc in NGM, CAG(GEDâ… -â…¡), CAG(GEDâ…¢) and GC and reveal the relations and significance among them from the level of genes and offer the ways to treat CAG. Method Apply S-P of immunohistochemical staining to detect the expressions of PTEN, P16, Bcl-2 and C-myc protein in 15 cases of NGM, 40 cases of CAG(GEDâ… -â…¡), 25cases of CAG(GEDâ…¢) and 35 cases of GC. Results 1 The positive rates of PTEN, Bcl-2 and C-myc protein expressions in NGM, CAG(GEDâ… -â…¡), CAG(GEDâ…¢) and GC were (100%, 100%, 40.0%, 34.3%), (13.3%, 17.5%, 60.0%, 57.1%) and (20%, 20%, 64.0%, 62.9%)respectively. There were no statistic significant differences between NGM and CAG(GEDâ… -â…¡) (P>0.05), and between CAG(GEDâ…¢) and GC (P>0.05). But the statistic significant differences was found between NGM and CAG(GEDâ…¢)(P<0.01), NGM and GC(P<0.05), CAG(GEDâ… -â…¡)and CAG(GEDâ…¢)(P<0.01), CAG(GEDâ… -â…¡) and GC(P<0.01). 2. The positive rate of P16 protein expression was low in NGM, CAG(GED â… -â…¡), CAG(GEDâ…¢) and GC, hence there was no significant statistic meaning among them. Conclusion 1. the expressions of PTEN, Bcl-2 and C-myc were no differences between NGM and CAG(GEDâ… -â…¡), CAG(GEDâ…¢)and GC group . but those differences can be found in any two groups. The result indicated that PTEN, Bcl-2 and C-myc can be used as relevant genes to detect GC. The surgery must be adopt to treat CAG(GEDâ…¢) . 2. the expression of p16 gene reveal low levels, it being used as a relevant gene to detect GC will be further studied.