The Study Of The Effect Of Point Application On Pulmonary Function And Cytokine Of COPD Patients

Objective: To discuss the curative effect and mechanisms of point application used in curing the acute exacerbations of chronic obstructive pulmonary disease. Methods: The 70 patients with acute exacerbations of chronic obstructive pulmonary disease were randomly divided into treatment group(36cases) and control group(34cases), the treatment group was treated by point application on the basis of regular method. The symptoms such as cough, sputum and stridor etc of both groups who were treated by point application for two weeks were observed. The serum levels of IL-2,TNF-a both of the admission of hospital and after being treated by ELISA method were measured in 64 cases of acute exacerbations of chronic obstructive pulmonary disease. Meanwhile the pulmonary function was also measured(FEV1%pre, FEV1/FVC, MVV, MMEF, FEF50, FEF75). Result: the trial was completed on 64 of 70 patients. (1) The clinical symptoms of TCM on both treatment group and control group were improved obviously (P<0.01) , and the effect oftreatment group was better than that of the control group (P<0.05) .There were not significant difference in statistics of the total efficiency (P>0.05).The effect in Heat-phlegm was better than that in cold -phlegm in treatment group(P<0.05).(2) After treatment, the levels of FEVl%Pre, FEV1/FVC and MMEF were better than before in two groups, but there were not any significant difference between both groups(P>0.05). After treatment the levels of FEF5(h FEF25^ MVV were all improved in two groups and in the treatment group,it was better than that in the control group(P<0.05).(3)The level of TNF2 was decreased and the level of IL-2 was increased in two groups after treatment, meanwhile in the treatment group it was better than in the control group( P<0.05 ).Conclusion: It is obvious that the use of point application can improve the clinical symptoms of TCM and pulmonary ventilation function and decrease the airway resistance. We can suspect that the treatment of point application may has not only the function to adjust cellular immunity and humoral immunity but also the power to reinforce patients' resistance from the effect on cytokine. It benefits patients' recovery.