A Study On The Structure And Properties Of Knitted Regeneration Conduits For Peripheral Nerve Repair

Recently, tissue engineering which integrates cell biology engineering material science and clinic physic and some other areas has gained more and more attentions from people. Textiles have new amalgamation with it. Peripheral regeneration conduits were presented in this paper. The nerve regeneration conduits are the tubes made from biological material or other materials, which are put into the defect nerves. Then the neural axons will regenerate from the proximal end to the distal end along the conduits. Nowadays, the studies from home and abroad are mainly on tensile properties vivo degradation properties and biological compatibility of different peripheral regeneration conduits and other mechanical properties and the analysis of related braided parameters are lacked very much. The study on properties in vivo degradation deals little with the changes of mechanical properties in vivo degradation. The parameters in braiding process and post-treatment process have some influence on mechanical properties and properties in vivo degradation, but the studies from home and abroad deal little with them.The influences on mechanical properties of peripheral regeneration conduits by different parameters in braiding process and post-treatment process were presented in this paper to find the best producing factors group. Besides ,the compressive properties torsion properties and weight loss rate of peripheral regeneration conduits in vivo degradation were discussed.The author used PGLA to braid conduits. By changing braided angle braided structure and coating treatment and using orthogonal design to find the best parameters and conditions with testing the influence of these parameters on the tensile properties compressive properties and torsion properties of peripheral nerve conduits.On the base of orthogonal design, the author did experiments on coating and no coating conduits in vivo degradation. The author analyzed the structure feature and compared the properties of peripheral nerve conduits by testing the compressive properties torsion properties and weight loss rate and observing the change of external shapes of coating and no coating conduits to find the best parameters in vivo degradation.New areas for clinical uses were pioneered in this paper. While studying the chosen parameters by orthogonal design, the author found coating treatment has obvious influence on peripheral nerve conduits. Besides, braided angle and braided structure have certain influence too. The degradation of PGLA peripheral nerve conduits was implemented byhydrolyzing of ester bond which is a chemical process. The losses of compressive properties and torsion properties were more quickly than weight loss, but the descending speeds compressive load and torsion load were not equally.The result of animal tests showed that peripheral nerve conduits coated by chitosan and sewn by guiding fiber have good repair effect. There are no obvious differences between this group and the autogenously graft group.