Effects Of Nicardiping On Bispectral Index In Patients During Anesthesia With Target-Controlled Infusion Of Propofol

Object To investigate the effects of nicardiping on bispectral index in patients during anesthesia with target-controlled infusion(TCI) of propofol. Methods Sixty ASA I - II patients aged between 22-60 yr and weighing 48-95 kg undergoing Laparoscopic cholecystectomy , were randomly allocated to one of four groups with 15 patients in each group: In propofol group(group P) anaesthesia was induced and maintained with propofol TCI;In nicardiping group I (group Nl), II (group N2) and 1 (group N3),anaesthesia was induced and maintained with propofol given by TCI and adjust target set to maintained bispectral index(BIS) with 45⁵5,given nicardiping 3ug ? kg^-1 > 6ug ? kg^-1, 9ug?kg^-1. All the patients anaesthesia were induced with fentanyl 3ug ? kg^-1, vecuronium0.12mg ? kg^-1.Target consentration of propofol ,BIS,MAP and HR were measured invasively pre-inductio(T0), pre-treatment(nicardiping or saline Tl),and at 1, 3, 5,10 min after treatment(T2,T3,T4,T5). Result (1)After nicardipine was intravenously injected,the value of the MAP decreased.Both the degree and the duration of this affection were positively correlation with the dosage of the nicardipine given: the higher the dosage.the longer the duration when the value of blood pressure decreased.(2)Heart rate increased while the blood pressure declining.Both the degree and duration of this increasing were positively correlation with the dosage of the nicardipine administrated.(3)The usage of ncardipine have no significant effect on the value of BIS. Conclusion Low-does nicardipine do not alter the bispectral index during anaesthesia with propofol.