Preparation Of Porous Gel-Coatings On Biomedical Titanium And The Physiological Function

Owing to the excellent mechanical properties of titanium and the bioactivities of hydroxyapatite (HA), the HA coating on titanium is regarded as a greatly promising implant in the area of hard tissue replacement. And also, the porous titanium (Ti) has been applied in this area. The newly born bone could be found in the pore space of the porous titanium, thus it is beneficial to the mechanical interlocking between the implant and natural bone. There is evidence that the HA layers on the porous Ti can accelerate the bone growth and enhance the bonding strength.The nano needle HA grains in natural human bone distribute directionally in the collagen network. Therefore, the syntheic nano needle HA similar to the natural human bone has a better bioactivity. On the other hand, drug delivery has been a new promising approach to curing for diseases, such as osteomyelitis and infective osteodefect. However, few attentions have been paid to the Ti-HA coating with Chinese traditional medicine (Salvia Miltiorrhize Bunge, SMB) as drug controlled release system. In this work, it was investigated.The porous layer was prepared on the Ti surface by micro-arc oxidation. Then the nano HA coating was formed on the Ti sample by sol-gel and mimic biomineralization. Additionally, the sample Ti was immersed in the supersaturated simulated body fluid (1.5SBF) with SMB (4:1, in volume) and cephalothin (1g/L) respectively to co-precipitate with the HA. The HA coating with medicine and therelease rate of the medicine were investigated.The results indicated that the nano-apatite coating with porous network was formed on anodic titanium oxide by sol-gel and then mimic biomineralization. The size of the network pores ranged from 5 urn to 30nm. The porous network titanium gel coating was fabricated by simple chemistry, the size of the network pores ranged from lum to 10nm. The porous calcium phosphate coating can be also obtained by mimic biomineralization and the size of the network pores ranged from lum to 25 (am which is larger than the substrate.As a hard tissue replacement implant, the porous HA layers are beneficial to protein absorption and cell adhesion and growth. The HA coating with proteins by co-preipitation in mimic biomineralization improved the cell adhesion and growth more. The HA coating with medicine will be helpful for the bone repair, and prevent and cure other bone diseases. Therefore, it can be concluded that the hard tissue replacement implant, with different or integral physiological functions, can be fabricated by the method discussed above.