Myocardial Protection Effect Of End Stage Half-Kalium Warm Blood Cardioplegia

Objective: To investigate the effect of myocardial protection of combing cold blood cardioplegia with half-kalium warm blood cardioplegia at end stage of cardiopulmonary bypass (CPB) delivering in cardiac valve replacement.Methods: 117 patients with cardiac valve replacement were investigated consecutively and divided randomly into four groups.(1) cold crystalloid cardioplegia;(2) cold blood cardioplegia;(3) full-kalium warm blood cardioplegia and (4) half-kalium warm blood cardioplegia. Serum creatine kinase(CK-MB) and kalium at deferent stage during and after CPB were measured. The mortality and mobility of low cardiac output syndrome were observed and recorded either.Result: The change trend of CK-MB change was similar in the four groups. But the level of CK-MB in half-kalium warm blood cardioplegia group was apparently lower at most stages after the coronary artery reperfusion. The result also showed that as soon as the coronary artery reperfused, K~+'s level was lower in half-kalium warm blood cardioplegia group than that in other groups. The mortality and mobility of low cardiac output syndrome in half-kalium warm blood cardioplegia group were lower than other groups.Conclusion: Combing cold blood cardioplegia with half-kalium warm blood cardioplegia at end stage of cardiopulmonary bypass (CPB) delivering is an ideal myocardial protection method in cardiac valve replacement.