The Study Of Functional MRI Data Processing

The research of human brain function is one of the popular focuses internationally nowadays. The application of Functional magnetic resonance imaging (fMRI) is more and more important in the research of human brain function with the constant development of magnetic resonance imaging. The research on brain function is mainly concentrated on the brain senior cognitive function presently. Within this research, the reasonable experimental design and scientific data analysis guarantee the reliable results. Therefore it is of great academic significance and valuable to do research on the experiment designing and data processing.This dissertation begins with the brief introduction of the basic structure and function of human brain, and then the rationale of magnetic resonance imaging (MRI) and biophysical mechanism of functional magnetic resonance imaging (fMRI). What follows is to discuss the experiment design with human bTain fMRI and data processing by SPM, which is popular used software internationally. The two common used experimental designs, block design and event related design are also introduced, and the latter one will be discussed in detail. Based on these methods, the fMRI data processing is detailed analyzed, the data pre-processing and statistical methods are introduced.In the end, a new method of data processing for block design is presented, that is to make use of event related method to process the data from block design experiment. Theoretically, this new method is much more accurate than the traditional methods.The data from block design of distinguishing the Chinese word from Chinese pseudo-word are processed and analyzed by this method and a new activated area (BA44) is found, which is inconspicuous by using traditional method. Therefore this new method is proved to be more accurate, scientific and feasible.